ID   MFS10_BOVIN             Reviewed;         456 AA.
AC   Q0P5M9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 10;
DE   AltName: Full=Tetracycline transporter-like protein;
GN   Name=MFSD10; Synonyms=TETRAN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI19846.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI19846.1};
RC   TISSUE=Thalamus {ECO:0000312|EMBL:AAI19846.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Confers cellular resistance to apoptosis induced by the non-
CC       steroidal anti-inflammatory drugs indomethacin and diclofenac. May act
CC       as an efflux pump (By similarity). {ECO:0000250|UniProtKB:Q14728}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q9D2V8}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000255}.
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DR   EMBL; BC119845; AAI19846.1; -; mRNA.
DR   RefSeq; NP_001068772.1; NM_001075304.1.
DR   RefSeq; XP_010804632.1; XM_010806330.2.
DR   AlphaFoldDB; Q0P5M9; -.
DR   SMR; Q0P5M9; -.
DR   STRING; 9913.ENSBTAP00000028155; -.
DR   PaxDb; Q0P5M9; -.
DR   PRIDE; Q0P5M9; -.
DR   Ensembl; ENSBTAT00000028155; ENSBTAP00000028155; ENSBTAG00000021130.
DR   GeneID; 507194; -.
DR   KEGG; bta:507194; -.
DR   CTD; 10227; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021130; -.
DR   VGNC; VGNC:31432; MFSD10.
DR   eggNOG; KOG2615; Eukaryota.
DR   GeneTree; ENSGT00830000128422; -.
DR   HOGENOM; CLU_001265_10_2_1; -.
DR   InParanoid; Q0P5M9; -.
DR   OrthoDB; 787769at2759; -.
DR   TreeFam; TF314512; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000021130; Expressed in thyroid gland and 104 other tissues.
DR   ExpressionAtlas; Q0P5M9; baseline.
DR   GO; GO:0031526; C:brush border membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 10"
FT                   /id="PRO_0000324657"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  48144 MW;  FD2F536393D06BF7 CRC64;
     MGCGAGGSCT PRPPIRQQQA PETRVVAVVF LGLLLDLLAF TLLLPLLPGL LESHGRAHDP
     LYGSWQRGVD WFAAAIGMPA EKRYNSVLFG GLIGSVFSLL QFLSAPLTGA LSDCLGRRPG
     MLLSLAGVAT SYAVWAASKS FAAFLASRVI GGISKGNVSL CTAIVADLGS PSARSKGMAV
     IGVAFSLGFT LGPTLGAFLP SETVPWLALL FAVSDLLFIW CFLPETLPPE KRAPSVTLGF
     RAAADLLSPL ALLRFSAVAR GPDPPTGVRL GSLRGLGLVY FLYLFLFSGL EFTLSFLVHQ
     RFRFSRVEQG KMFFFIGLTM ATIQGAYARR IRPGREIAAV KQAILLLIPA SLFVGWGHTL
     PILGLGLLLY SWAAAVVVPC LSSVVAGYGS PGQKGTVMGT LRSLGALARA VGPVVAASAY
     WLAGARVCYT VCAALFLLPF SILRTLSPPA RTLKAE