位置:首页 > 蛋白库 > MFS10_MOUSE
MFS10_MOUSE
ID   MFS10_MOUSE             Reviewed;         456 AA.
AC   Q9D2V8; Q3U800; Q3UN73; Q9D1A7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 10;
DE   AltName: Full=Tetracycline transporter-like protein;
GN   Name=Mfsd10; Synonyms=Tetran;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAB31378.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB31378.1}, and
RC   NOD {ECO:0000312|EMBL:BAC40724.1};
RC   TISSUE=Bone marrow {ECO:0000312|EMBL:BAE31219.1},
RC   Cerebellum {ECO:0000312|EMBL:BAE25874.1},
RC   Embryo {ECO:0000312|EMBL:BAB22982.1}, Kidney {ECO:0000312|EMBL:BAB31378.1},
RC   and Thymus {ECO:0000312|EMBL:BAC40724.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2] {ECO:0000312|EMBL:AAH23012.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3 {ECO:0000312|EMBL:AAH23012.1}, and
RC   ICR {ECO:0000312|EMBL:AAH64775.1};
RC   TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH23012.1}, and
RC   Trophoblast stem cell {ECO:0000312|EMBL:AAH64775.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=31142202; DOI=10.1080/19491034.2019.1618175;
RA   Cheng L.C., Baboo S., Lindsay C., Brusman L., Martinez-Bartolome S.,
RA   Tapia O., Zhang X., Yates J.R. III, Gerace L.;
RT   "Identification of new transmembrane proteins concentrated at the nuclear
RT   envelope using organellar proteomics of mesenchymal cells.";
RL   Nucleus 10:126-143(2019).
CC   -!- FUNCTION: Confers cellular resistance to apoptosis induced by the non-
CC       steroidal anti-inflammatory drugs indomethacin and diclofenac. May act
CC       as an efflux pump (By similarity). {ECO:0000250|UniProtKB:Q14728}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000269|PubMed:31142202}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB22982.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK003763; BAB22982.1; ALT_INIT; mRNA.
DR   EMBL; AK018736; BAB31378.1; -; mRNA.
DR   EMBL; AK089055; BAC40724.1; -; mRNA.
DR   EMBL; AK144407; BAE25874.1; -; mRNA.
DR   EMBL; AK152438; BAE31219.1; -; mRNA.
DR   EMBL; BC023012; AAH23012.1; -; mRNA.
DR   EMBL; BC064775; AAH64775.1; -; mRNA.
DR   CCDS; CCDS19217.1; -.
DR   RefSeq; NP_080936.1; NM_026660.2.
DR   RefSeq; XP_006504140.1; XM_006504077.3.
DR   RefSeq; XP_006504141.1; XM_006504078.3.
DR   RefSeq; XP_011239069.1; XM_011240767.2.
DR   RefSeq; XP_011239070.1; XM_011240768.2.
DR   RefSeq; XP_017176573.1; XM_017321084.1.
DR   AlphaFoldDB; Q9D2V8; -.
DR   SMR; Q9D2V8; -.
DR   BioGRID; 212789; 3.
DR   STRING; 10090.ENSMUSP00000001109; -.
DR   TCDB; 2.A.1.2.73; the major facilitator superfamily (mfs).
DR   GlyGen; Q9D2V8; 1 site.
DR   PhosphoSitePlus; Q9D2V8; -.
DR   SwissPalm; Q9D2V8; -.
DR   EPD; Q9D2V8; -.
DR   MaxQB; Q9D2V8; -.
DR   PaxDb; Q9D2V8; -.
DR   PRIDE; Q9D2V8; -.
DR   ProteomicsDB; 295600; -.
DR   Antibodypedia; 8956; 80 antibodies from 21 providers.
DR   DNASU; 68294; -.
DR   Ensembl; ENSMUST00000001109; ENSMUSP00000001109; ENSMUSG00000001082.
DR   Ensembl; ENSMUST00000114329; ENSMUSP00000109968; ENSMUSG00000001082.
DR   Ensembl; ENSMUST00000114331; ENSMUSP00000109970; ENSMUSG00000001082.
DR   GeneID; 68294; -.
DR   KEGG; mmu:68294; -.
DR   UCSC; uc008xct.1; mouse.
DR   CTD; 10227; -.
DR   MGI; MGI:1915544; Mfsd10.
DR   VEuPathDB; HostDB:ENSMUSG00000001082; -.
DR   eggNOG; KOG2615; Eukaryota.
DR   GeneTree; ENSGT00940000164295; -.
DR   InParanoid; Q9D2V8; -.
DR   OMA; ACFSVAF; -.
DR   OrthoDB; 787769at2759; -.
DR   PhylomeDB; Q9D2V8; -.
DR   TreeFam; TF314512; -.
DR   BioGRID-ORCS; 68294; 3 hits in 77 CRISPR screens.
DR   ChiTaRS; Mfsd10; mouse.
DR   PRO; PR:Q9D2V8; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9D2V8; protein.
DR   Bgee; ENSMUSG00000001082; Expressed in yolk sac and 223 other tissues.
DR   ExpressionAtlas; Q9D2V8; baseline and differential.
DR   Genevisible; Q9D2V8; MM.
DR   GO; GO:0031526; C:brush border membrane; IDA:MGI.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
DR   GO; GO:0008514; F:organic anion transmembrane transporter activity; ISO:MGI.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043252; P:sodium-independent organic anion transport; ISO:MGI.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 10"
FT                   /id="PRO_0000324659"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        177
FT                   /note="G -> R (in Ref. 1; BAB22982)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        340
FT                   /note="V -> M (in Ref. 1; BAE31219)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        384
FT                   /note="M -> L (in Ref. 1; BAE31219)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   456 AA;  49369 MW;  242AD79516B266F6 CRC64;
     MGWAGDAGCT PRPPIRPRPA SERRVIIVLF LGLLLDLLAF TLLLPLLPGL LERHGREQDP
     LYGSWQRGVD WFASAIGMPA EKRYNSVLFG GLIGSAFSLL QFFSAPLTGA ASDYLGRRPV
     MMLSLTGLAI SYAVWATSRS FKAFLASRVI GGISKGNVNL STAIVADLGS PPTRSQGMAV
     IGVAFSLAFT LGPMLGAFLS VEMVPWISLL FAISDMLFIF CFLPETLPQE KRASSVTLGF
     HTAAHLLSPL ALLRFAAVTH SQDPPAEHRL RNLRRLGLVY FLYLFLFSGL EYTLSFLAHQ
     RFQFSSLQQG KMFFFIGLTM ATIQGTYARR ISPGKEAAAV TRAMLLLVPA FLLIGWAHSL
     PTLGLGLMLY SFAAAVVVPG LSTMVSSYGS PGQKGTIMGI LRSLGALGRA LGPVVAASVY
     WLTGAQVCFT VCSALFLLPF LLLWKLKHPA ETSKEE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024