MFS11_MOUSE
ID MFS11_MOUSE Reviewed; 449 AA.
AC Q8BJ51; A2AA30; A2AA32; B2RQK5; O54844; Q8BJ61;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=UNC93-like protein MFSD11;
DE AltName: Full=Major facilitator superfamily domain-containing protein 11;
DE AltName: Full=Protein ET;
GN Name=Mfsd11; Synonyms=Et;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-434 (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=9358160; DOI=10.1093/nar/25.22.4513;
RA Sureau A., Soret J., Guyon C., Gaillard C., Dumon S., Keller M.,
RA Crisanti P., Perbal B.;
RT "Characterization of multiple alternative RNAs resulting from antisense
RT transcription of the PR264/SC35 splicing factor gene.";
RL Nucleic Acids Res. 25:4513-4522(1997).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJ51-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJ51-2; Sequence=VSP_028189;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9358160}.
CC -!- SIMILARITY: Belongs to the unc-93 family. {ECO:0000305}.
CC -!- CAUTION: Despite its name it is related to the unc-93 family and not to
CC the major facilitator superfamily. {ECO:0000305}.
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DR EMBL; AK031384; BAC27376.1; -; mRNA.
DR EMBL; AK032043; BAC27666.1; -; mRNA.
DR EMBL; AL645542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC088988; AAH88988.1; -; mRNA.
DR EMBL; BC137970; AAI37971.1; -; mRNA.
DR EMBL; BC137971; AAI37972.1; -; mRNA.
DR EMBL; AF015191; AAB92498.1; -; mRNA.
DR CCDS; CCDS25681.1; -. [Q8BJ51-1]
DR RefSeq; NP_848735.1; NM_178620.3. [Q8BJ51-1]
DR RefSeq; XP_006534205.1; XM_006534142.3. [Q8BJ51-1]
DR RefSeq; XP_006534206.1; XM_006534143.3. [Q8BJ51-1]
DR RefSeq; XP_006534207.1; XM_006534144.3. [Q8BJ51-1]
DR RefSeq; XP_017170234.1; XM_017314745.1. [Q8BJ51-1]
DR AlphaFoldDB; Q8BJ51; -.
DR SMR; Q8BJ51; -.
DR STRING; 10090.ENSMUSP00000021173; -.
DR TCDB; 2.A.1.58.3; the major facilitator superfamily (mfs).
DR GlyGen; Q8BJ51; 1 site.
DR iPTMnet; Q8BJ51; -.
DR PhosphoSitePlus; Q8BJ51; -.
DR PaxDb; Q8BJ51; -.
DR PeptideAtlas; Q8BJ51; -.
DR PRIDE; Q8BJ51; -.
DR Antibodypedia; 19710; 53 antibodies from 13 providers.
DR DNASU; 69900; -.
DR Ensembl; ENSMUST00000021173; ENSMUSP00000021173; ENSMUSG00000020818. [Q8BJ51-1]
DR Ensembl; ENSMUST00000153084; ENSMUSP00000123368; ENSMUSG00000020818. [Q8BJ51-2]
DR GeneID; 69900; -.
DR KEGG; mmu:69900; -.
DR UCSC; uc007mmp.1; mouse. [Q8BJ51-1]
DR CTD; 79157; -.
DR MGI; MGI:1917150; Mfsd11.
DR VEuPathDB; HostDB:ENSMUSG00000020818; -.
DR eggNOG; KOG3098; Eukaryota.
DR GeneTree; ENSGT00390000012918; -.
DR HOGENOM; CLU_025356_2_0_1; -.
DR InParanoid; Q8BJ51; -.
DR OMA; CIGAVNR; -.
DR OrthoDB; 663893at2759; -.
DR PhylomeDB; Q8BJ51; -.
DR TreeFam; TF315284; -.
DR BioGRID-ORCS; 69900; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Mfsd11; mouse.
DR PRO; PR:Q8BJ51; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BJ51; protein.
DR Bgee; ENSMUSG00000020818; Expressed in spermatocyte and 226 other tissues.
DR ExpressionAtlas; Q8BJ51; baseline and differential.
DR Genevisible; Q8BJ51; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..449
FT /note="UNC93-like protein MFSD11"
FT /id="PRO_0000305021"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 114..165
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_028189"
FT CONFLICT 46
FT /note="G -> S (in Ref. 4; AAB92498)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="S -> P (in Ref. 4; AAB92498)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="I -> T (in Ref. 4; AAB92498)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="A -> V (in Ref. 4; AAB92498)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="A -> D (in Ref. 1; BAC27376)"
FT /evidence="ECO:0000305"
FT CONFLICT 431
FT /note="A -> T (in Ref. 4; AAB92498)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 49133 MW; E578DD7132D9A45B CRC64;
MSPESKKLFN IVILGVAFMF MFTAFQTCGN VAQTVIRSLN STDFHGSGYT SLAIIYGVFS
ASNLITPSVV AIVGPQISMF VSGLFYSMYI AVFIQPFPWS FYTASVFIGI AAAVLWTAQG
NCLTINSDEH TIGRNSGIFW ALLQSSLFFG NLYIYFAWQG KTQISEHDRR TVFIALTVIS
LVGTVLFFLI RKPDPENVLG EEESCDDQDM EATESAQNNV TKAVDAFKKS LRLCVTREML
LLSVTTAYTG LELTFFSGVY GTCIGAVNKF GTEEKSLIGL SGIFIGIGEI LGGSLFGLLS
KNSRFGRNPV VLLGTLVHFV AFYLIFLNMP GDAPIAPVEG TNSIAYIRPS KEVAILCSFL
LGLGDSCFNT QLLSILGFLY SEDSAPAFAV FKFVQSICAA VAFFYSNYLL LHWQLLVMVI
FGFFGTISFF AVEWDAAAIV ARGSDYRSI
