MFS11_PONAB
ID MFS11_PONAB Reviewed; 449 AA.
AC Q5RCQ5; Q5RE53;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=UNC93-like protein MFSD11;
DE AltName: Full=Major facilitator superfamily domain-containing protein 11;
GN Name=MFSD11;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RCQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RCQ5-2; Sequence=VSP_028190;
CC -!- SIMILARITY: Belongs to the unc-93 family. {ECO:0000305}.
CC -!- CAUTION: Despite its name it is related to the unc-93 family and not to
CC the major facilitator superfamily. {ECO:0000305}.
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DR EMBL; CR857684; CAH89954.1; -; mRNA.
DR EMBL; CR858214; CAH90452.1; -; mRNA.
DR RefSeq; NP_001125232.1; NM_001131760.1. [Q5RCQ5-1]
DR AlphaFoldDB; Q5RCQ5; -.
DR SMR; Q5RCQ5; -.
DR STRING; 9601.ENSPPYP00000009737; -.
DR GeneID; 100172125; -.
DR KEGG; pon:100172125; -.
DR CTD; 79157; -.
DR eggNOG; KOG3098; Eukaryota.
DR InParanoid; Q5RCQ5; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..449
FT /note="UNC93-like protein MFSD11"
FT /id="PRO_0000305022"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BJ51"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..209
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028190"
SQ SEQUENCE 449 AA; 49156 MW; F39FFF8154D44040 CRC64;
MSPESKKLFN IIILGVAFMF MFTAFQTCGN VAQTVIRSLN STDFHGSGYT SMAIIYGVFS
ASNLITPPVV AIVGPQLSMF ASGLFYSMYI AVFNQPFPWS FYTASVFIGI AAAVLWTAQG
NCLTINSDEH TIGRNSGIFW ALLQSSLFFG NLYVYFAWQG KTQISESDRR TVFIALTVIS
LVGTVLFFLI RKPDSENVLG EDESSDDQDM EVNESAQNNL TKAVDAFKKS FKLCVTKEML
LLSITTAYTG LELTFFSGVY GTCIGAINKF GAEEKSLIGL SGIFIGIGEI LGGSLFGLLS
KNNRFGRNPV VLLGILVHFI AFYLIFLNMP GDAPIAPVKG TDSSAYIKSS KEVAILCSFL
LGLGDSCFNT QLLSILGFLY SEDSAPAFAI FKFVQSICAA VAFFYSNYLL LHWQLLVMVI
FGFFGTLSFF TVEWEAAAFV ARGSDYRSI
