ID   MFS1_AJECA              Reviewed;         560 AA.
AC   B2KWH5;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=MFS siderochrome iron transporter 1 {ECO:0000303|PubMed:18404210};
GN   Name=MFS1 {ECO:0000303|PubMed:18404210};
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=18404210; DOI=10.1371/journal.ppat.1000044;
RA   Hwang L.H., Mayfield J.A., Rine J., Sil A.;
RT   "Histoplasma requires SID1, a member of an iron-regulated siderophore gene
RT   cluster, for host colonization.";
RL   PLoS Pathog. 4:E1000044-E1000044(2008).
CC   -!- FUNCTION: Major facilitator transporter involved in siderophore
CC       transport (PubMed:18404210). {ECO:0000269|PubMed:18404210}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is induced during iron deprivation
CC       (PubMed:18404210). {ECO:0000269|PubMed:18404210}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU253970; ACC64448.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2KWH5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..560
FT                   /note="MFS siderochrome iron transporter 1"
FT                   /id="PRO_0000444409"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        404
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   560 AA;  60879 MW;  BF2EEABCDBC77A49 CRC64;
     MVTLSNVGAD VEKNIVPEVN DASKRDSDNA SADFQPGVKR VRAVASVWSK KTLWLTFALL
     YLVAFVDMLL VSVQSTLNPF ITSSFEKHGL LASVSIVATI LSGCSTLTLA KIVDVWGRIE
     GFLFMLLVVV VALIMKATCK NMEAYVAAHT LYWTGHIGMI YCVDVMLADM TTLRNRMIMF
     SINNTPTIAS TFAGPKIADL FFSNLNFRWA FGAFAIMLVG VSLPVIVIML FMERKSVKAG
     FLVKEKSGRS AWESIKYHLI EFDVVGIVLI TASFALILLP FSIVVYAPKG WATGYIIAME
     VVGVVCGAIF LAWERFLAPV QFLPFKYLKN PTIIGSCLLY GVMFASALLT ITTAGYVLNS
     FSLSSAILAP GIGLYTGNFK WAAYAGIPFM LLGTALLIPF RQPNTSIGAV TITQVLVGIG
     TSFFSVCGQL AVMSVVSHQE VAVVLAIWGM FGSIGASVGL AVAGAMWNNI LPSQLYRRLP
     EESKAMAAQI FGDMQLQMSY LDGTPERDAI VGAYADVQRK MVIAGVCMMP LVMASIVIWR
     NVNIKKQEEE EGSQTTGNIF