ID   MFS2_AJECA              Reviewed;         588 AA.
AC   B2KWH6;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=MFS siderochrome iron transporter 1 {ECO:0000303|PubMed:18404210};
GN   Name=MFS2 {ECO:0000303|PubMed:18404210};
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=18404210; DOI=10.1371/journal.ppat.1000044;
RA   Hwang L.H., Mayfield J.A., Rine J., Sil A.;
RT   "Histoplasma requires SID1, a member of an iron-regulated siderophore gene
RT   cluster, for host colonization.";
RL   PLoS Pathog. 4:E1000044-E1000044(2008).
CC   -!- FUNCTION: Major facilitator transporter involved in siderophore
CC       transport (PubMed:18404210). {ECO:0000269|PubMed:18404210}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is induced during iron deprivation
CC       (PubMed:18404210). {ECO:0000269|PubMed:18404210}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU253971; ACC64449.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2KWH6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..588
FT                   /note="MFS siderochrome iron transporter 1"
FT                   /id="PRO_0000444410"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        519
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   588 AA;  64631 MW;  F9F17F9622CCDE4E CRC64;
     MRSAFLSKLQ THAPVAQPQV ISSGLAKEAG DLPQEQEVDA EDQLSADAQD GVRKIQATTQ
     VWSKGHLIFA YVMIWVITFV DTMQQGMSNS LLPYVTSSFR LHSLTASTMI MSNIIGGLIK
     LPLAKVLDIW GRPQGFLIMV GALTIGLVMM AACNNVKTYA AAQVFYWVGY NGMSYTISIF
     IADTSALKNR ALMFAFVSSP YIATVWVGGP LATVFLNGPG FRWGYGAFAI ITPAITCPLY
     AVFAWNYKKA KDAGLLPEKT HSRTFTQSLK HYFFEFDIIG IILLASGLAL FLLPFSLYSY
     QKDQWRSSLV ISMIIVGGLL LIAFALYEKY RAPVCFIPFE LLFDRTVLGA CILAASLFVS
     FYIWDSYFSS FLQIVNDLSI TQASYIVNIY SIGACFWSII VGILVRWSGR FKWLALYFGV
     PLTILGVGLM ITFRQPDVNI GYIIMCQIFI AFAGGTCVIT EQMAVMAATS HQYVAVVLAV
     ESMFANIGGA IGQTVAAAIW TGVFPQRLAE YLPDEAKANA TLIYGDLTVQ KSYPVGSLER
     IAINRAYGDG QKYMLIGGTA ILAVGLGATM MWRDIKVKDF KQVKGLVV