ID   MFS2_SCHPO              Reviewed;         546 AA.
AC   Q10084;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Uncharacterized transporter mfs2;
GN   Name=mfs2; ORFNames=SPAC11D3.05;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAA92306.1; -; Genomic_DNA.
DR   PIR; T37516; T37516.
DR   RefSeq; NP_592802.1; NM_001018202.2.
DR   AlphaFoldDB; Q10084; -.
DR   BioGRID; 279429; 2.
DR   STRING; 4896.SPAC11D3.05.1; -.
DR   MaxQB; Q10084; -.
DR   PaxDb; Q10084; -.
DR   EnsemblFungi; SPAC11D3.05.1; SPAC11D3.05.1:pep; SPAC11D3.05.
DR   GeneID; 2542991; -.
DR   KEGG; spo:SPAC11D3.05; -.
DR   PomBase; SPAC11D3.05; mfs2.
DR   VEuPathDB; FungiDB:SPAC11D3.05; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   HOGENOM; CLU_008455_11_6_1; -.
DR   InParanoid; Q10084; -.
DR   OMA; FCTFPYL; -.
DR   PhylomeDB; Q10084; -.
DR   PRO; PR:Q10084; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISM:PomBase.
DR   GO; GO:0022857; F:transmembrane transporter activity; ISM:PomBase.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:UniProt.
DR   GO; GO:0055085; P:transmembrane transport; ISM:PomBase.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..546
FT                   /note="Uncharacterized transporter mfs2"
FT                   /id="PRO_0000173444"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        510..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   546 AA;  61058 MW;  6E002A37D33C2637 CRC64;
     MDLLSLITGK KFEKHYSKVG SRFSDESLNG LEKQLSNGAD AAIDTTADDR GSVVSLGASL
     PLSQGRPAKS KNILNDTLLA EDQYLVTWDG PDDPLNPRNW SHSYKWWIVI QVSVITIVVT
     FASSVYSSGI IDIASELHSS IPVSTLGSCT FLVGFGVGSL PFAPLSDIYG RFIIYFVTLL
     IFTIFQVGGG CAHNVWTLAI VRFFQGVFGS TPLANAGGTI SDLFTPVQRT YVLPGFCTFP
     YLGPIIGPII GDFITQSYLE WRWTFWINMI WAAAVIVFVF IFFPETHEDT ILDYKAKYLR
     KTTGNTAYYT IHERERDPKN AMIQAATQAV SLIFTEPIVV CFTLYLTVVY IINYINFEGY
     PIVFAKYGFN KGEQGLSFIG VGVGIVCAGL CTPFIYWHYL KVNKKRNGVI CPEDRLYPLF
     IGCFLLPISM FWFAWTCYPH HIHWIVPIIA SAFFGFSLLI VFFVSYNYII DSYQHMAPSA
     LAAATLVRYS ASGGISMVAR PMYLNLGDHW ATSVLGFISV AMVPIPFIFY RFGKSIRAWS
     KNAYKL