ID   MFS4B_DANRE             Reviewed;         594 AA.
AC   A4QN56;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Sodium-dependent glucose transporter 1 {ECO:0000250|UniProtKB:Q80T22};
DE   AltName: Full=Major facilitator superfamily domain-containing protein 4B;
GN   Name=mfsd4b; Synonyms=naglt1; ORFNames=zgc:162161;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=WIK; TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a sodium-dependent glucose transporter.
CC       Potential channels for urea in the inner medulla of kidney.
CC       {ECO:0000250|UniProtKB:Q80T22}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q80T22}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC134911; AAI34912.1; -; mRNA.
DR   RefSeq; NP_001082989.1; NM_001089520.1.
DR   AlphaFoldDB; A4QN56; -.
DR   SMR; A4QN56; -.
DR   STRING; 7955.ENSDARP00000101496; -.
DR   PaxDb; A4QN56; -.
DR   GeneID; 100037368; -.
DR   KEGG; dre:100037368; -.
DR   CTD; 91749; -.
DR   ZFIN; ZDB-GENE-070410-26; mfsd4b.
DR   eggNOG; ENOG502R5UW; Eukaryota.
DR   InParanoid; A4QN56; -.
DR   OrthoDB; 1122917at2759; -.
DR   PhylomeDB; A4QN56; -.
DR   Reactome; R-DRE-189200; Cellular hexose transport.
DR   PRO; PR:A4QN56; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Sugar transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..594
FT                   /note="Sodium-dependent glucose transporter 1"
FT                   /id="PRO_0000294515"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   594 AA;  64081 MW;  F29A80A97C62C9DB CRC64;
     MSPAEAAPRK KHVRFARMEG DVDHDDQEEN TLFDKQKDVK EGLKSVLKGG KGILSQGSGQ
     VDVVRPGRSK TGTCWRWLVS LALCASFLGL GMAISVLGPT FEDLAINVNK NISNLSYIFV
     GRASGYIGGS LLGGILFDFV NPHLLLGFAL LTTAFGMSGT PFCKKAWVLT VLMSSVGVSM
     GVLDTGGNVL ILNTWGEQAG PHMQALHFSF AAGAFASPII AKLLFGHHNS STNTSLMSGH
     ASKTIDAVLP FSHPKGTSTI DLPWMWAYIV IGAFVLLVSL LFFSLYFCIS TNSNRTKTAS
     GKQQFSKHHN TLIILLSMFF FFYVGSEVAY GSFIFTYGKD YVHMEETEAA GLNSLFWGAF
     AAGRGLAIFF AACLHPGTLI LLSLVGTTVS SLLLCLFSQN YPMLWACTAL YGISMSTTFP
     SGISWVEQYT TVTGRSAAIF VVGAALGEMV LPALLGFLLG HVQNYPLLMY LTLCTATFTS
     ILFPVLYKLA SPEGNVTLRK SSGKCTIKDA DDSEYRQALL ENMEEQEENE SEADLCNDAD
     FEVIEMDDAS LLSSPKSSPP ADVAASVPDV HLVASPLSEP NMLSFSTDSP RSKL