ID   MFS4B_XENLA             Reviewed;         491 AA.
AC   Q569T7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Sodium-dependent glucose transporter 1 {ECO:0000250|UniProtKB:Q80T22};
DE   AltName: Full=Major facilitator superfamily domain-containing protein 4B;
GN   Name=mfsd4b; Synonyms=naglt1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a sodium-dependent glucose transporter.
CC       Potential channels for urea in the inner medulla of kidney.
CC       {ECO:0000250|UniProtKB:Q80T22}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:Q80T22}; Multi-pass membrane protein
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC092312; AAH92312.1; -; mRNA.
DR   RefSeq; NP_001089348.1; NM_001095879.1.
DR   RefSeq; XP_018120053.1; XM_018264564.1.
DR   AlphaFoldDB; Q569T7; -.
DR   SMR; Q569T7; -.
DR   TCDB; 2.A.1.7.23; the major facilitator superfamily (mfs).
DR   DNASU; 734398; -.
DR   GeneID; 734398; -.
DR   KEGG; xla:734398; -.
DR   CTD; 734398; -.
DR   Xenbase; XB-GENE-5884015; mfsd4b.S.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 734398; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Sugar transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..491
FT                   /note="Sodium-dependent glucose transporter 1"
FT                   /id="PRO_0000294516"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          397..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  53397 MW;  96F7109BC9AB0680 CRC64;
     MAIAVLGPTF LDLAENVESS VANISFIFVG RSMGYLGGSV LGGILFEQIN QHLLLGISML
     ATAAGLFVVP WCKKAVLLTA VMSVVGMSMG FLDTGGNIII LNTWEDQAGP HIQALHFSFA
     LGAFVAPILA KLALEFLPLD KKSFNVSEPF LEQSALPFGI KKSMLSYIVI GTYILLVSLF
     LFILFSKSRP RQSSGKASDD KFRTARYHNA VIFLLFLFFF CYVGAEVAYG SYIFTYAITY
     ITNIENNYAA GLNSLFWGVF AAVRGLAICF ATCLYPGTML LLSVIGCTLS SLILVLFSRN
     HLLLWVGTAV YGASMATTFP SGFSWVQQYT TIGGKSASLF VVGAALGEMA IPASVGYLQG
     MFPNFPVLMY TALASSTMTA ILFPVMYKLA TAQQDQAQYN RVESDDRRAL LSSSGMEEED
     EDEAQNWNEA DFETIEMNDQ MKNSVTVISE DTPGNSAPSE ILKHSTKSNG AEAAANKSPS
     RKHNTDREKN D