ID   MFS6L_MOUSE             Reviewed;         586 AA.
AC   Q8R3N2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 6-like;
GN   Name=Mfsd6l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC       {ECO:0000305}.
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DR   EMBL; BC024997; AAH24997.1; -; mRNA.
DR   CCDS; CCDS24867.1; -.
DR   RefSeq; NP_666116.1; NM_146004.1.
DR   AlphaFoldDB; Q8R3N2; -.
DR   STRING; 10090.ENSMUSP00000061601; -.
DR   iPTMnet; Q8R3N2; -.
DR   PhosphoSitePlus; Q8R3N2; -.
DR   PaxDb; Q8R3N2; -.
DR   PRIDE; Q8R3N2; -.
DR   ProteomicsDB; 292314; -.
DR   Antibodypedia; 12633; 15 antibodies from 10 providers.
DR   DNASU; 215723; -.
DR   Ensembl; ENSMUST00000053211; ENSMUSP00000061601; ENSMUSG00000048329.
DR   GeneID; 215723; -.
DR   KEGG; mmu:215723; -.
DR   UCSC; uc007jnv.1; mouse.
DR   CTD; 162387; -.
DR   MGI; MGI:2384904; Mfsd6l.
DR   VEuPathDB; HostDB:ENSMUSG00000048329; -.
DR   eggNOG; KOG3762; Eukaryota.
DR   GeneTree; ENSGT00530000063599; -.
DR   HOGENOM; CLU_013133_4_0_1; -.
DR   InParanoid; Q8R3N2; -.
DR   OMA; GQLDCFL; -.
DR   OrthoDB; 453672at2759; -.
DR   PhylomeDB; Q8R3N2; -.
DR   TreeFam; TF314366; -.
DR   BioGRID-ORCS; 215723; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Mfsd6l; mouse.
DR   PRO; PR:Q8R3N2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8R3N2; protein.
DR   Bgee; ENSMUSG00000048329; Expressed in spermatocyte and 35 other tissues.
DR   Genevisible; Q8R3N2; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR024989; MFS_assoc_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF12832; MFS_1_like; 1.
DR   SUPFAM; SSF103473; SSF103473; 2.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..586
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 6-like"
FT                   /id="PRO_0000321945"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        494..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        519..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          218..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  63430 MW;  FBD7BF16BB23E37E CRC64;
     MSPNPQWDVP RALRVARLFH LVCGVRDACV TPFLTLYLRQ LGVAAPLVGI LMGTKHLIAT
     CWIPFCAFLA KRYQKRRMFL TGSLLSSAGA SLLMVLVPPV DRNLVNHFCN GSSRVATTIL
     PLGVTQTVIM TPTQGSGAPN LPGSRHTRAL DTSGFPNGSE GTFSGLQTYL VGSVEGARTT
     TQGLHLVTSG LRDNSQKGTF EVGNVTLNLL PGSTALGGPV NLSKPQGDTQ TPDHSSKGSP
     WTFILSLGVV VFWELLAAPL EQVADDSLYE YLDFVDATDR NRDLWVWKLL GVSAGVCGIA
     ALVGHLECLL VANGPQGVIY FYSYSLVSTL ALAVSTAFPV PIDQQQGPSY KAIKALSLIR
     GDSRLILLAF TVFWIGATAS TVQDFLFWHM KDHGSSELVM GFSVALSLLG EILFHPFRTS
     LLRKLSRVGV LGLGLGCLAL QVLYYAFIWS WWSVLPVQIL STISSGALWW AVGASIEDLA
     FSGMERSLGT MFRGHFYGSG CSLGSFVGGF VVLHFGIAVL YEACCVVLLL WLALFLSIQP
     RLPQEQRINY SKLLAMGGSD SSDSEQGSEG DWLVKAMREE HSDWKG