MFSA_ASPFU
ID MFSA_ASPFU Reviewed; 542 AA.
AC Q4WC50;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Major facilitator superfamily transporter mfsA {ECO:0000303|PubMed:16622700};
GN Name=mfsA {ECO:0000303|PubMed:16622700}; Synonyms=stl1;
GN ORFNames=AFUA_8G05710;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP IDENTIFICATION, FUNCTION, AND INDUCTION.
RX PubMed=16622700; DOI=10.1007/s00294-006-0073-2;
RA da Silva Ferreira M.E., Malavazi I., Savoldi M., Brakhage A.A.,
RA Goldman M.H., Kim H.S., Nierman W.C., Goldman G.H.;
RT "Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.";
RL Curr. Genet. 50:32-44(2006).
RN [3]
RP INDUCTION.
RX PubMed=18648542; DOI=10.1371/journal.pone.0002655;
RA Sugui J.A., Kim H.S., Zarember K.A., Chang Y.C., Gallin J.I., Nierman W.C.,
RA Kwon-Chung K.J.;
RT "Genes differentially expressed in conidia and hyphae of Aspergillus
RT fumigatus upon exposure to human neutrophils.";
RL PLoS ONE 3:E2655-E2655(2008).
RN [4]
RP INDUCTION.
RX PubMed=21264256; DOI=10.1371/journal.pone.0016016;
RA Morton C.O., Varga J.J., Hornbach A., Mezger M., Sennefelder H., Kneitz S.,
RA Kurzai O., Krappmann S., Einsele H., Nierman W.C., Rogers T.R.,
RA Loeffler J.;
RT "The temporal dynamics of differential gene expression in Aspergillus
RT fumigatus interacting with human immature dendritic cells in vitro.";
RL PLoS ONE 6:E16016-E16016(2011).
CC -!- FUNCTION: Major facilitator superfamily transporter that may be
CC involved in A.fumigatus adaptation to azoles such as vorizonazole.
CC {ECO:0000305|PubMed:16622700}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein.
CC -!- INDUCTION: Expression is induced upon voriconazole treatment
CC (PubMed:16622700). Expression is up-regulated by exposure to human
CC monocyte-derived immature dendritic cells (PubMed:21264256). Expression
CC is also up-regulated in conidia exposed to human neutrophils
CC (PubMed:18648542). {ECO:0000269|PubMed:16622700,
CC ECO:0000269|PubMed:18648542, ECO:0000269|PubMed:21264256}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AAHF01000013; EAL85334.1; -; Genomic_DNA.
DR RefSeq; XP_747372.1; XM_742279.1.
DR AlphaFoldDB; Q4WC50; -.
DR SMR; Q4WC50; -.
DR STRING; 746128.CADAFUBP00007968; -.
DR EnsemblFungi; EAL85334; EAL85334; AFUA_8G05710.
DR GeneID; 3504696; -.
DR KEGG; afm:AFUA_8G05710; -.
DR VEuPathDB; FungiDB:Afu8g05710; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_3_1; -.
DR InParanoid; Q4WC50; -.
DR OMA; ENLHMEK; -.
DR OrthoDB; 430696at2759; -.
DR Proteomes; UP000002530; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0015793; P:glycerol transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..542
FT /note="Major facilitator superfamily transporter mfsA"
FT /id="PRO_0000445110"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 542 AA; 60110 MW; 4074F95FE63743F1 CRC64;
MWTTTSGLSG RSLRLSITFA AVVGFSLFGY NQGMMAGLLN GDEFVNSFPI LKMPDNPTAG
EKHYIDVIRG AVTSCYELGC FFGALFSMFC GNRLGRTRLI FMGASILIVG ALLTTVCYTG
KWEVGQFVIG RVVSGIGNGM NTATIPVWQS ECSGAHNRGF LVCFEGAMIA GGTFIAYWVV
FGISHAADSV QWRFPVALQI FFALVVATGA LMLPDSPSWF VSRGLDNEAC EVLGKIKGTS
PDSDQVLHDF NLIKTDMEST KSEQSNWKTV FTFGKTQEFQ RLLIGCSGQF FQQFTGCNAA
IYYSTLLFQE NLHMEKYLSL IMGGVFASVY ALATIPSFFM IERVGRRKLY LIGFLGQGLS
FVITFACLIK ETEENSKGAA VGIFLFITFF AFTLLPLPWI YPPEINPLRT RTVGASASTC
TNWMCNFAVV MFTPLFAGQS PWGVYLFFAL FNFVGLIFGY FFYVETAGRE LEEVDIIYAK
AHVEGKMPFR VAHDLPKLSF EEIVQQSREL GLDTNDHVML EKKELGLSSD SAQETEEVYE
KQ
