MFSB_ASPFU
ID MFSB_ASPFU Reviewed; 602 AA.
AC Q4WRQ4;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Major facilitator superfamily multidrug transporter mfsB {ECO:0000303|PubMed:16622700};
GN Name=mfsB {ECO:0000303|PubMed:16622700}; ORFNames=AFUA_1G15490;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP IDENTIFICATION, INDUCTION, AND FUNCTION.
RX PubMed=16622700; DOI=10.1007/s00294-006-0073-2;
RA da Silva Ferreira M.E., Malavazi I., Savoldi M., Brakhage A.A.,
RA Goldman M.H., Kim H.S., Nierman W.C., Goldman G.H.;
RT "Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.";
RL Curr. Genet. 50:32-44(2006).
CC -!- FUNCTION: Major facilitator superfamily transporter that may be
CC involved in A.fumigatus adaptation to azoles such as vorizonazole.
CC {ECO:0000305|PubMed:16622700}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein.
CC -!- INDUCTION: Expression is induced upon voriconazole treatment.
CC {ECO:0000269|PubMed:16622700}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AAHF01000004; EAL90878.1; -; Genomic_DNA.
DR RefSeq; XP_752916.1; XM_747823.1.
DR AlphaFoldDB; Q4WRQ4; -.
DR STRING; 330879.Q4WRQ4; -.
DR EnsemblFungi; EAL90878; EAL90878; AFUA_1G15490.
DR GeneID; 3509940; -.
DR KEGG; afm:AFUA_1G15490; -.
DR VEuPathDB; FungiDB:Afu1g15490; -.
DR eggNOG; KOG2615; Eukaryota.
DR HOGENOM; CLU_001265_54_5_1; -.
DR InParanoid; Q4WRQ4; -.
DR OMA; LAWWACG; -.
DR OrthoDB; 1090653at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..602
FT /note="Major facilitator superfamily multidrug transporter
FT mfsB"
FT /id="PRO_0000445108"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 527..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66079 MW; F0342209FA8F7889 CRC64;
MFKRPSFLRR QRHTVGRDDW SAFPVRQLFV LALCRICEPI AFMSIFPYVY HMVEAFKVTD
DDHKIALYAG LITSSFTFAE FSAGMFWGRM SDKIGRKPVL IMGLIGTAIS MIVFGFAPNL
PTAMVARALG GLLNGNIGVL QTTVAEIVTV KEHQPRAYSI MPFVWCLGSI IGPAMGGALA
QPCQNYPGLF QRHTIFDSFP FLLPNLVCVV VLVFGVIVGF LFLEETHPEK RYRRDPGLEL
GNWLIARCSG SRVQLTEDDT DIKVDANEAD YFNYGDVPPP EYRSTETSPQ LAPIKNVGAL
SGDDDIEGQV KGEQCGTPKA FTKQVIFNIV AYGILAYHSV SFDQLIPVFL STPKSDDNFV
LPFKFTGGLG LPTKTIGFML AVQGVYSMIA QLWLFPFVVR HFGTLRTFRL VLLVWPPLYM
LVPYLVLLPS ILQTAAVYLA LISKITLHVI AFPSTAILLA NAAPSSKVLG SINGAAASTA
SLSRALGPTI TGLLHSKGLE SGYSIIAWWA CGLVCVTGTI QSFWMEESEP RRDSEKAGNS
DSTAGIPMRS SFPAGKEYAT PEEERRLLSS TRTSVDDLDI SNLDLTQIEP APRSNPLAFA
ED
