MFSC_ASPFU
ID MFSC_ASPFU Reviewed; 518 AA.
AC Q4WKA1;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Major facilitator superfamily multidrug transporter mfsC {ECO:0000303|PubMed:16622700};
GN Name=mfsC {ECO:0000303|PubMed:16622700}; ORFNames=AFUA_1G03200;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP IDENTIFICATION, INDUCTION, AND FUNCTION.
RX PubMed=16622700; DOI=10.1007/s00294-006-0073-2;
RA da Silva Ferreira M.E., Malavazi I., Savoldi M., Brakhage A.A.,
RA Goldman M.H., Kim H.S., Nierman W.C., Goldman G.H.;
RT "Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.";
RL Curr. Genet. 50:32-44(2006).
RN [3]
RP INDUCTION.
RX PubMed=18796135; DOI=10.1186/1471-2164-9-417;
RA Lamarre C., Sokol S., Debeaupuis J.P., Henry C., Lacroix C., Glaser P.,
RA Coppee J.Y., Francois J.M., Latge J.P.;
RT "Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus
RT conidia.";
RL BMC Genomics 9:417-417(2008).
CC -!- FUNCTION: Major facilitator superfamily transporter that may be
CC involved in A.fumigatus adaptation to azoles such as vorizonazole.
CC {ECO:0000305|PubMed:16622700}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein.
CC -!- INDUCTION: Expression is induced upon voriconazole treatment
CC (PubMed:16622700). Expression is also induced during germination
CC (PubMed:18796135). {ECO:0000269|PubMed:16622700,
CC ECO:0000269|PubMed:18796135}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000305}.
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DR EMBL; AAHF01000007; EAL88031.1; -; Genomic_DNA.
DR RefSeq; XP_750069.1; XM_744976.1.
DR AlphaFoldDB; Q4WKA1; -.
DR SMR; Q4WKA1; -.
DR STRING; 746128.CADAFUBP00000353; -.
DR EnsemblFungi; EAL88031; EAL88031; AFUA_1G03200.
DR GeneID; 3507949; -.
DR KEGG; afm:AFUA_1G03200; -.
DR VEuPathDB; FungiDB:Afu1g03200; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_28_2_1; -.
DR InParanoid; Q4WKA1; -.
DR OMA; FNTAYQV; -.
DR OrthoDB; 595536at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..518
FT /note="Major facilitator superfamily multidrug transporter
FT mfsC"
FT /id="PRO_0000445109"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 518 AA; 54450 MW; F32665389E677E63 CRC64;
MTSNKKSRLP PYQPGEHVSP SVHLNCVLLT TTVVNFLDLF QLSSVLFALP NIQQALGFAS
EDINWVLIVY NITFAAFLLI AGQLGQRFGL EKIFIAGTAT LTISNVINTT APNKGALLAG
RAISGVGAGL TAPNGLAILS NTFPDPESRN KALAIYTACG PLGSTIGTVV GSHLACMSGW
RSIFWLCLIL TGLSTILACL FLPRFAKRKD MPIDIPGTVV FTAGVALLVY GLNDSSRRGW
TSAAMLTGII LGVCLLFVFL WVEAKVSNPA ISSYLWKSGP FLVMLVAIFA FGGSFSTWFF
ISTQLCVNLL GYSTILTAVY FLPAAFAAIA SGVFATPLIR LAGEKNILVA GLAITAAGAV
AWAFAGPRIG PAVPTTGRDT AIIFVIGSPV ALVPTQSILL REVEAGNHAV AGALFNTAYQ
VGASVILAGA NALMDRSRAN VQGVRQVTID GYLNAFWLIA GVLGAAALTV MVCYWPGKDD
LVERQTEEAN AVGPLAVDKV DTSKDATASA RSVADTRL
