ID   MFSD1_CHICK             Reviewed;         442 AA.
AC   Q5ZIT9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 1;
GN   Name=MFSD1; ORFNames=RCJMB04_23j9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Lysosomal transporter which is essential for liver
CC       homeostasis. Required to maintain stability and lysosomal localization
CC       of GLMP. {ECO:0000250|UniProtKB:Q9DC37}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9DC37}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9DC37};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- DOMAIN: The dileucine internalization motif is required for lysosomal
CC       localization. {ECO:0000250|UniProtKB:Q9DC37}.
CC   -!- PTM: Not N-glycosylated. {ECO:0000250|UniProtKB:Q9DC37}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ720695; CAG32354.1; -; mRNA.
DR   RefSeq; NP_001026492.1; NM_001031321.1.
DR   AlphaFoldDB; Q5ZIT9; -.
DR   SMR; Q5ZIT9; -.
DR   STRING; 9031.ENSGALP00000015616; -.
DR   Ensembl; ENSGALT00000072984; ENSGALP00000045908; ENSGALG00000009593.
DR   GeneID; 425017; -.
DR   KEGG; gga:425017; -.
DR   CTD; 64747; -.
DR   VEuPathDB; HostDB:geneid_425017; -.
DR   eggNOG; KOG4686; Eukaryota.
DR   GeneTree; ENSGT00390000011700; -.
DR   InParanoid; Q5ZIT9; -.
DR   PhylomeDB; Q5ZIT9; -.
DR   PRO; PR:Q5ZIT9; -.
DR   Proteomes; UP000000539; Chromosome 9.
DR   Bgee; ENSGALG00000009593; Expressed in spermatocyte and 14 other tissues.
DR   ExpressionAtlas; Q5ZIT9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..442
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 1"
FT                   /id="PRO_0000273385"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           8..9
FT                   /note="Dileucine internalization motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DC37"
SQ   SEQUENCE   442 AA;  48162 MW;  4B7642028EC8EAF9 CRC64;
     MAEEERALLG PDGGDGGSAA PPRALPAVCD PSRLPHRLLV LALMCFLGFG SCFCYDNPAA
     LQTQVQGDMK VNTARFMALY AWLGTVIFSI FVCVGQVIFA LGALVNAFWL MEVGRFIFGI
     GGESLAVAQN TYAVSWFKGK ELNLVFGLQL SMARIGSTVN MNIMGWIYSR VQDLLGHTGH
     ATLGLTLLIG GITCLFSLAC ALILAYLDKR AEKLLCKEQG KTGEVIKLTD VKNFSLSLWL
     IFVICVCYYA AVFPFIGLGK VFFIEKFQFS SQEASAINSV VYIISAPMSP VFGILVDKVG
     KNIIWVLCAV ITTLASHIML AFTFWNPWIA MCLLGVAYSL LACALWPMVA FVVPEHQLGT
     AYGFMQSIQN LGLAVIAIAA GMILDTRGYL FLEVFFSACV SLSLVAVVML YFVNHLTGGD
     LNWSAKKREK LQKVAANDLL YC