MFSD3_HUMAN
ID MFSD3_HUMAN Reviewed; 412 AA.
AC Q96ES6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Major facilitator superfamily domain-containing protein 3;
GN Name=MFSD3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96ES6; Q13520: AQP6; NbExp=3; IntAct=EBI-745345, EBI-13059134;
CC Q96ES6; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-745345, EBI-12012928;
CC Q96ES6; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-745345, EBI-6163737;
CC Q96ES6; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-745345, EBI-13292283;
CC Q96ES6; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-745345, EBI-988826;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC011982; AAH11982.1; -; mRNA.
DR CCDS; CCDS6431.1; -.
DR RefSeq; NP_612440.1; NM_138431.2.
DR AlphaFoldDB; Q96ES6; -.
DR BioGRID; 125254; 21.
DR IntAct; Q96ES6; 11.
DR MINT; Q96ES6; -.
DR STRING; 9606.ENSP00000301327; -.
DR iPTMnet; Q96ES6; -.
DR PhosphoSitePlus; Q96ES6; -.
DR BioMuta; MFSD3; -.
DR DMDM; 74731607; -.
DR EPD; Q96ES6; -.
DR jPOST; Q96ES6; -.
DR MassIVE; Q96ES6; -.
DR MaxQB; Q96ES6; -.
DR PaxDb; Q96ES6; -.
DR PeptideAtlas; Q96ES6; -.
DR PRIDE; Q96ES6; -.
DR ProteomicsDB; 76445; -.
DR Antibodypedia; 28578; 92 antibodies from 15 providers.
DR DNASU; 113655; -.
DR Ensembl; ENST00000301327.5; ENSP00000301327.3; ENSG00000167700.9.
DR GeneID; 113655; -.
DR KEGG; hsa:113655; -.
DR MANE-Select; ENST00000301327.5; ENSP00000301327.3; NM_138431.3; NP_612440.1.
DR UCSC; uc003zdi.2; human.
DR CTD; 113655; -.
DR DisGeNET; 113655; -.
DR GeneCards; MFSD3; -.
DR HGNC; HGNC:25157; MFSD3.
DR HPA; ENSG00000167700; Low tissue specificity.
DR neXtProt; NX_Q96ES6; -.
DR OpenTargets; ENSG00000167700; -.
DR PharmGKB; PA142671464; -.
DR VEuPathDB; HostDB:ENSG00000167700; -.
DR eggNOG; KOG3574; Eukaryota.
DR GeneTree; ENSGT00940000154019; -.
DR HOGENOM; CLU_029352_2_1_1; -.
DR InParanoid; Q96ES6; -.
DR OMA; ANPFYVD; -.
DR OrthoDB; 716614at2759; -.
DR PhylomeDB; Q96ES6; -.
DR TreeFam; TF330933; -.
DR PathwayCommons; Q96ES6; -.
DR SignaLink; Q96ES6; -.
DR BioGRID-ORCS; 113655; 17 hits in 1076 CRISPR screens.
DR ChiTaRS; MFSD3; human.
DR GenomeRNAi; 113655; -.
DR Pharos; Q96ES6; Tdark.
DR PRO; PR:Q96ES6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96ES6; protein.
DR Bgee; ENSG00000167700; Expressed in mucosa of transverse colon and 114 other tissues.
DR Genevisible; Q96ES6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR004752; AmpG_permease/AT-1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR12778; PTHR12778; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..412
FT /note="Major facilitator superfamily domain-containing
FT protein 3"
FT /id="PRO_0000273392"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 292
FT /note="G -> R (in dbSNP:rs2306387)"
FT /id="VAR_030141"
SQ SEQUENCE 412 AA; 42696 MW; 1F472D45C64187A3 CRC64;
MRGKLLPLAG LYLVQGLPYG LQSGLLPVLL RAGGLSLTRV GLAKVLYAPW LLKLAWAPLV
DAQGSARAWV TRSTAGLGLV CGLLAGLPPP GAGQAGLPAA VAGLLLLLNL GAAMQDVALD
ALAVQLLEPA ELGPGNTVQV VAYKLGAALA GGALLALLPT FSWPQLFLLL AATYWLAAAL
AWAAPALRRL PQQPPSEQRP HTAHLLRDVL AVPGTVWTAG FVLTYKLGEQ GASSLFPLLL
LDHGVSAPEL GLWNGVGAVV CSIAGSSLGG TLLAKHWKLL PLLRSVLRFR LGGLACQTAL
VFHLDTLGAS MDAGTILRGS ALLSLCLQHF LGGLVTTVTF TGMMRCSQLA PRALQATHYS
LLATLELLGK LLLGTLAGGL ADGLGPHPCF LLLLILSAFP VLYLDLAPST FL
