ID   MFSD3_RAT               Reviewed;         416 AA.
AC   Q4V8E5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 3;
GN   Name=Mfsd3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC097424; AAH97424.1; -; mRNA.
DR   RefSeq; NP_001020079.1; NM_001024908.1.
DR   AlphaFoldDB; Q4V8E5; -.
DR   SMR; Q4V8E5; -.
DR   STRING; 10116.ENSRNOP00000021208; -.
DR   TCDB; 2.A.1.57.6; the major facilitator superfamily (mfs).
DR   PaxDb; Q4V8E5; -.
DR   Ensembl; ENSRNOT00000021208; ENSRNOP00000021208; ENSRNOG00000015685.
DR   GeneID; 500899; -.
DR   KEGG; rno:500899; -.
DR   UCSC; RGD:1560274; rat.
DR   CTD; 113655; -.
DR   RGD; 1560274; Mfsd3.
DR   eggNOG; KOG3574; Eukaryota.
DR   GeneTree; ENSGT00940000154019; -.
DR   HOGENOM; CLU_029352_2_1_1; -.
DR   InParanoid; Q4V8E5; -.
DR   OMA; ANPFYVD; -.
DR   OrthoDB; 716614at2759; -.
DR   PhylomeDB; Q4V8E5; -.
DR   TreeFam; TF330933; -.
DR   PRO; PR:Q4V8E5; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000015685; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; Q4V8E5; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR004752; AmpG_permease/AT-1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR12778; PTHR12778; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..416
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 3"
FT                   /id="PRO_0000273394"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   416 AA;  43513 MW;  CA7B0F3C4A3FDE4A CRC64;
     MHGKLLPLAG LYLVQGLPYG LQSSLLPILL RARGLSLTRV GLTKGLYAPW LLKLAWAPLV
     DRRGTPRVWL TFSTVCLGLV CGLLAVLPPP QAGQTGLPTT VMGLLLLLNL GAAVQDVALD
     TLAVQLLEPK ELGPGNTVQV VAYKLGSALA GGGLLVFFPT LSWPLLFLLL TATYWLAAAL
     AWAAPALGRL SRPQVSEHTP HTSYLLQDLL AVPGTLWTAG FVLTYKMGEQ GAGSLFPLLL
     LDHGASASDL GLWSGLGAAT CSIAGSSLGG ALLARHCSHP RQPLKLLRSV LQLRLGGLAC
     QTALLLHLNT PGASLDPGTV MRGAALLSLC LQQFLGGVVT TATFTVMMHC SQLAPRALQA
     THYSFLATLE LLGKLLPGTL AGVLADGLGP RLCFAAFLVL SALPVLDLRL APSNLT