ID   MFSD5_BOVIN             Reviewed;         450 AA.
AC   Q0VC03;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=MFSD5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC120417; AAI20418.1; -; mRNA.
DR   RefSeq; NP_001068808.1; NM_001075340.1.
DR   AlphaFoldDB; Q0VC03; -.
DR   SMR; Q0VC03; -.
DR   STRING; 9913.ENSBTAP00000011760; -.
DR   PaxDb; Q0VC03; -.
DR   PRIDE; Q0VC03; -.
DR   Ensembl; ENSBTAT00000011760; ENSBTAP00000011760; ENSBTAG00000008933.
DR   GeneID; 507921; -.
DR   KEGG; bta:507921; -.
DR   CTD; 84975; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008933; -.
DR   VGNC; VGNC:31440; MFSD5.
DR   eggNOG; KOG4332; Eukaryota.
DR   GeneTree; ENSGT00390000012629; -.
DR   HOGENOM; CLU_034007_2_0_1; -.
DR   InParanoid; Q0VC03; -.
DR   OMA; CCGWVVL; -.
DR   OrthoDB; 565504at2759; -.
DR   TreeFam; TF328562; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000008933; Expressed in esophagus and 104 other tissues.
DR   ExpressionAtlas; Q0VC03; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..450
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273400"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  49842 MW;  E9428EADB7902231 CRC64;
     MLVTAYLAFV VLLASCLGLE LSRCRAKPSG RACSNPSFLR FQLDFYQVYF LALAADWLQA
     PYLYKLYQHY HFLEAQIAIL YVCGLASTVL FGLVASSLVD WLGRKKSCVL FSLTYSLCCL
     TKLSRDYFVL LVGRALGGLS TALLFSAFEA WYIHEHLERH DFPTEWIPAT FARAAFWNHV
     LAVAAGVAAE AVACWMGLGP VAPFVAAIPL LALAGALALH NWGENYDRQR AFSRTCAGGL
     RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
     IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS
     MSFLRRKVIP ETEQAGVLNW FRVPLHLLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL
     LAVVGLFTVV RHDAELRVPS PTGEPYTPEL