ID   MFSD5_DANRE             Reviewed;         481 AA.
AC   Q6DG19;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=mfsd5; ORFNames=zgc:91807;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC076536; AAH76536.1; -; mRNA.
DR   RefSeq; NP_001002713.1; NM_001002713.1.
DR   RefSeq; XP_005162430.1; XM_005162373.3.
DR   RefSeq; XP_005162431.1; XM_005162374.3.
DR   RefSeq; XP_009295317.1; XM_009297042.2.
DR   AlphaFoldDB; Q6DG19; -.
DR   STRING; 7955.ENSDARP00000004281; -.
DR   TCDB; 2.A.1.40.1; the major facilitator superfamily (mfs).
DR   PaxDb; Q6DG19; -.
DR   Ensembl; ENSDART00000011004; ENSDARP00000004281; ENSDARG00000015997.
DR   GeneID; 436986; -.
DR   KEGG; dre:436986; -.
DR   CTD; 84975; -.
DR   ZFIN; ZDB-GENE-040718-468; mfsd5.
DR   eggNOG; KOG4332; Eukaryota.
DR   GeneTree; ENSGT00390000012629; -.
DR   HOGENOM; CLU_034007_2_0_1; -.
DR   InParanoid; Q6DG19; -.
DR   OMA; CCGWVVL; -.
DR   OrthoDB; 565504at2759; -.
DR   PhylomeDB; Q6DG19; -.
DR   TreeFam; TF328562; -.
DR   PRO; PR:Q6DG19; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000015997; Expressed in blastula and 22 other tissues.
DR   ExpressionAtlas; Q6DG19; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..481
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273404"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  52789 MW;  6F7E6E829C5E2900 CRC64;
     MFVTAYLAFI VLAGLCVALE ITARRLTLSQ ATQTAVANPA FQRFQKLFLK AYLLALWADW
     LQGPYLYKLY RHYNFLESQI AILYVCGLAS CVLFAPVAGW LPQFLGRRQT CLLFCLAYSV
     CCITKLSQDY FMLILGRVLG GLSTSLLTTT FEAWYVHGHV DIHDFPKEWI PVTFGKVANW
     NYGLAVGAGL VANLFAEWLG LGPVAPFLLA IPSLAACAWF VLSEWGQEDK QEGMNGDKNA
     PLLNSLNTPK LQLSARARFW RSCVDGLRCL LSDRRVMLLG GVQALFESVL YIFVFLWTPV
     LDPHGPPLGI VFSSLMAATM AGSTLFRLAT SAPYRLQPGH LLCLAILLAF FSFFMLTFST
     VPGQPRPRES LLAFLLLELA CGLYFPAVSF LQGRVVPVER RAAVLAWFRL PLHLLACLGL
     LALHGEVSGS GAGEAGSGTR HMFAGCAGMM LAALLAVISL FTVGRNDADL RLEGPKLEGE
     I