MFSD5_HUMAN
ID MFSD5_HUMAN Reviewed; 450 AA.
AC Q6N075; G3V1N7; Q6NW04; Q8N7W8; Q8NCK0; Q96IA5;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Molybdate-anion transporter;
DE AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE AltName: Full=Molybdate transporter 2 homolog;
DE Short=hsMOT2;
GN Name=MFSD5; ORFNames=UNQ832/PRO1759;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=21044875; DOI=10.1016/j.gene.2010.10.011;
RA Sreedharan S., Stephansson O., Schioth H.B., Fredriksson R.;
RT "Long evolutionary conservation and considerable tissue specificity of
RT several atypical solute carrier transporters.";
RL Gene 478:11-18(2011).
RN [9]
RP FUNCTION, AND BIOPHYSICOCHEMICAL PROPERTIES.
RX PubMed=21464289; DOI=10.1073/pnas.1100700108;
RA Tejada-Jimenez M., Galvan A., Fernandez E.;
RT "Algae and humans share a molybdate transporter.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6420-6425(2011).
CC -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC oligo-element molybdenum. {ECO:0000269|PubMed:21464289}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=546 nM for molybdate (when expressed in yeast)
CC {ECO:0000269|PubMed:21464289};
CC -!- INTERACTION:
CC Q6N075; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-3920969, EBI-11277970;
CC Q6N075; Q13520: AQP6; NbExp=3; IntAct=EBI-3920969, EBI-13059134;
CC Q6N075; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-3920969, EBI-714543;
CC Q6N075; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-3920969, EBI-19947314;
CC Q6N075; P62952: BLCAP; NbExp=3; IntAct=EBI-3920969, EBI-3895726;
CC Q6N075; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-3920969, EBI-17953245;
CC Q6N075; O14523: C2CD2L; NbExp=3; IntAct=EBI-3920969, EBI-12822627;
CC Q6N075; Q8N350-4: CBARP; NbExp=3; IntAct=EBI-3920969, EBI-19051169;
CC Q6N075; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-3920969, EBI-10271156;
CC Q6N075; P25942: CD40; NbExp=3; IntAct=EBI-3920969, EBI-525714;
CC Q6N075; P11912: CD79A; NbExp=3; IntAct=EBI-3920969, EBI-7797864;
CC Q6N075; O95471: CLDN7; NbExp=3; IntAct=EBI-3920969, EBI-740744;
CC Q6N075; P58418: CLRN1; NbExp=3; IntAct=EBI-3920969, EBI-17274839;
CC Q6N075; Q96BA8: CREB3L1; NbExp=6; IntAct=EBI-3920969, EBI-6942903;
CC Q6N075; O43169: CYB5B; NbExp=3; IntAct=EBI-3920969, EBI-1058710;
CC Q6N075; O15552: FFAR2; NbExp=3; IntAct=EBI-3920969, EBI-2833872;
CC Q6N075; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-3920969, EBI-12175685;
CC Q6N075; P36382: GJA5; NbExp=3; IntAct=EBI-3920969, EBI-750433;
CC Q6N075; O14653: GOSR2; NbExp=3; IntAct=EBI-3920969, EBI-4401517;
CC Q6N075; Q96P66: GPR101; NbExp=3; IntAct=EBI-3920969, EBI-17935713;
CC Q6N075; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-3920969, EBI-13345167;
CC Q6N075; O00155: GPR25; NbExp=3; IntAct=EBI-3920969, EBI-10178951;
CC Q6N075; O15529: GPR42; NbExp=3; IntAct=EBI-3920969, EBI-18076404;
CC Q6N075; Q8TED1: GPX8; NbExp=3; IntAct=EBI-3920969, EBI-11721746;
CC Q6N075; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-3920969, EBI-18053395;
CC Q6N075; P24593: IGFBP5; NbExp=3; IntAct=EBI-3920969, EBI-720480;
CC Q6N075; Q6UWB1: IL27RA; NbExp=3; IntAct=EBI-3920969, EBI-19045531;
CC Q6N075; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-3920969, EBI-749265;
CC Q6N075; O43561-2: LAT; NbExp=3; IntAct=EBI-3920969, EBI-8070286;
CC Q6N075; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-3920969, EBI-2820517;
CC Q6N075; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-3920969, EBI-6163737;
CC Q6N075; P15941-11: MUC1; NbExp=3; IntAct=EBI-3920969, EBI-17263240;
CC Q6N075; O15173: PGRMC2; NbExp=3; IntAct=EBI-3920969, EBI-1050125;
CC Q6N075; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-3920969, EBI-12257782;
CC Q6N075; P26678: PLN; NbExp=3; IntAct=EBI-3920969, EBI-692836;
CC Q6N075; P50876: RNF144A; NbExp=3; IntAct=EBI-3920969, EBI-2340657;
CC Q6N075; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-3920969, EBI-2466594;
CC Q6N075; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-3920969, EBI-10244780;
CC Q6N075; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-3920969, EBI-17247926;
CC Q6N075; O75396: SEC22B; NbExp=3; IntAct=EBI-3920969, EBI-1058865;
CC Q6N075; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-3920969, EBI-18037857;
CC Q6N075; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-3920969, EBI-18159983;
CC Q6N075; Q05940: SLC18A2; NbExp=3; IntAct=EBI-3920969, EBI-18036244;
CC Q6N075; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-3920969, EBI-2823239;
CC Q6N075; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-3920969, EBI-17280858;
CC Q6N075; P02808: STATH; NbExp=3; IntAct=EBI-3920969, EBI-738687;
CC Q6N075; Q0VAB0: TBXA2R; NbExp=3; IntAct=EBI-3920969, EBI-18271435;
CC Q6N075; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-3920969, EBI-6268651;
CC Q6N075; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-3920969, EBI-10694905;
CC Q6N075; Q8N3G9: TMEM130; NbExp=3; IntAct=EBI-3920969, EBI-19763514;
CC Q6N075; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-3920969, EBI-8638294;
CC Q6N075; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-3920969, EBI-11724423;
CC Q6N075; Q969S6: TMEM203; NbExp=3; IntAct=EBI-3920969, EBI-12274070;
CC Q6N075; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-3920969, EBI-10982110;
CC Q6N075; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-3920969, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6N075-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6N075-2; Sequence=VSP_046647;
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously but at relatively higher
CC levels in the olfactory bulb and the skeletal muscle.
CC {ECO:0000269|PubMed:21044875}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=CAE45795.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358604; AAQ88967.1; -; mRNA.
DR EMBL; BX640649; CAE45795.1; ALT_INIT; mRNA.
DR EMBL; AK097576; BAC05108.1; ALT_SEQ; mRNA.
DR EMBL; AK074684; BAC11137.1; -; mRNA.
DR EMBL; AC021072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW96679.1; -; Genomic_DNA.
DR EMBL; BC007703; AAH07703.1; -; mRNA.
DR EMBL; BC067795; AAH67795.1; -; mRNA.
DR CCDS; CCDS53796.1; -. [Q6N075-2]
DR CCDS; CCDS8851.1; -. [Q6N075-1]
DR RefSeq; NP_001164261.1; NM_001170790.1. [Q6N075-2]
DR RefSeq; NP_116278.3; NM_032889.4. [Q6N075-1]
DR RefSeq; XP_005269254.1; XM_005269197.1. [Q6N075-2]
DR RefSeq; XP_005269255.1; XM_005269198.4. [Q6N075-1]
DR AlphaFoldDB; Q6N075; -.
DR SMR; Q6N075; -.
DR BioGRID; 124404; 84.
DR IntAct; Q6N075; 72.
DR MINT; Q6N075; -.
DR STRING; 9606.ENSP00000442688; -.
DR TCDB; 2.A.1.40.2; the major facilitator superfamily (mfs).
DR iPTMnet; Q6N075; -.
DR PhosphoSitePlus; Q6N075; -.
DR SwissPalm; Q6N075; -.
DR BioMuta; MFSD5; -.
DR DMDM; 124015161; -.
DR EPD; Q6N075; -.
DR jPOST; Q6N075; -.
DR MassIVE; Q6N075; -.
DR MaxQB; Q6N075; -.
DR PaxDb; Q6N075; -.
DR PeptideAtlas; Q6N075; -.
DR PRIDE; Q6N075; -.
DR ProteomicsDB; 32391; -.
DR ProteomicsDB; 66618; -. [Q6N075-1]
DR ProteomicsDB; 66619; -. [Q6N075-2]
DR Antibodypedia; 48343; 91 antibodies from 14 providers.
DR DNASU; 84975; -.
DR Ensembl; ENST00000329548.5; ENSP00000332624.5; ENSG00000182544.9. [Q6N075-1]
DR Ensembl; ENST00000534842.1; ENSP00000442688.1; ENSG00000182544.9. [Q6N075-2]
DR GeneID; 84975; -.
DR KEGG; hsa:84975; -.
DR MANE-Select; ENST00000329548.5; ENSP00000332624.5; NM_032889.5; NP_116278.3.
DR UCSC; uc001sch.3; human. [Q6N075-1]
DR CTD; 84975; -.
DR GeneCards; MFSD5; -.
DR HGNC; HGNC:28156; MFSD5.
DR HPA; ENSG00000182544; Low tissue specificity.
DR neXtProt; NX_Q6N075; -.
DR OpenTargets; ENSG00000182544; -.
DR PharmGKB; PA142671466; -.
DR VEuPathDB; HostDB:ENSG00000182544; -.
DR eggNOG; KOG4332; Eukaryota.
DR GeneTree; ENSGT00390000012629; -.
DR HOGENOM; CLU_034007_2_0_1; -.
DR InParanoid; Q6N075; -.
DR OrthoDB; 845354at2759; -.
DR PhylomeDB; Q6N075; -.
DR TreeFam; TF328562; -.
DR PathwayCommons; Q6N075; -.
DR SignaLink; Q6N075; -.
DR BioGRID-ORCS; 84975; 13 hits in 1077 CRISPR screens.
DR ChiTaRS; MFSD5; human.
DR GenomeRNAi; 84975; -.
DR Pharos; Q6N075; Tdark.
DR PRO; PR:Q6N075; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6N075; protein.
DR Bgee; ENSG00000182544; Expressed in lower esophagus mucosa and 182 other tissues.
DR ExpressionAtlas; Q6N075; baseline and differential.
DR Genevisible; Q6N075; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR030163; MFSD5.
DR InterPro; IPR008509; MOT2/MFSD5.
DR PANTHER; PTHR23516; PTHR23516; 1.
DR PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR Pfam; PF05631; MFS_5; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..450
FT /note="Molybdate-anion transporter"
FT /id="PRO_0000273401"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MEVTAVGEEANQGDLLGFGQRCCSLGSSNPWLYRTAGIFPEHCTEEK
FT KIGTYFRVAPQASKSQRSRCHGMAASEARPGEATAASYGRPFPTHPRRQEFRARVVRGP
FT TM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046647"
FT CONFLICT 130
FT /note="L -> M (in Ref. 5; AAH67795)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="V -> A (in Ref. 4; BAC11137)"
FT /evidence="ECO:0000305"
FT CONFLICT 425
FT /note="G -> E (in Ref. 2; CAE45795)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 450 AA; 49765 MW; A15D005755941BA7 CRC64;
MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF LALAADWLQA
PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL
TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV
LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL
RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS
MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL
LAVVGLFTVV RHDAELRVPS PTEEPYAPEL
