MFSD5_MOUSE
ID MFSD5_MOUSE Reviewed; 450 AA.
AC Q921Y4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Molybdate-anion transporter;
DE AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE AltName: Full=Molybdate transporter 2 homolog;
GN Name=Mfsd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC oligo-element molybdenum. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AK089268; BAC40821.1; -; mRNA.
DR EMBL; BC009140; AAH09140.1; -; mRNA.
DR CCDS; CCDS27877.1; -.
DR RefSeq; NP_598861.1; NM_134100.4.
DR AlphaFoldDB; Q921Y4; -.
DR SMR; Q921Y4; -.
DR STRING; 10090.ENSMUSP00000061997; -.
DR iPTMnet; Q921Y4; -.
DR PhosphoSitePlus; Q921Y4; -.
DR SwissPalm; Q921Y4; -.
DR EPD; Q921Y4; -.
DR jPOST; Q921Y4; -.
DR MaxQB; Q921Y4; -.
DR PaxDb; Q921Y4; -.
DR PeptideAtlas; Q921Y4; -.
DR PRIDE; Q921Y4; -.
DR ProteomicsDB; 292231; -.
DR Antibodypedia; 48343; 91 antibodies from 14 providers.
DR Ensembl; ENSMUST00000051341; ENSMUSP00000061997; ENSMUSG00000045665.
DR GeneID; 106073; -.
DR KEGG; mmu:106073; -.
DR UCSC; uc007xve.1; mouse.
DR CTD; 84975; -.
DR MGI; MGI:2145901; Mfsd5.
DR VEuPathDB; HostDB:ENSMUSG00000045665; -.
DR eggNOG; KOG4332; Eukaryota.
DR GeneTree; ENSGT00390000012629; -.
DR HOGENOM; CLU_034007_2_0_1; -.
DR InParanoid; Q921Y4; -.
DR OMA; CCGWVVL; -.
DR OrthoDB; 565504at2759; -.
DR PhylomeDB; Q921Y4; -.
DR TreeFam; TF328562; -.
DR BioGRID-ORCS; 106073; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Mfsd5; mouse.
DR PRO; PR:Q921Y4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q921Y4; protein.
DR Bgee; ENSMUSG00000045665; Expressed in lip and 257 other tissues.
DR Genevisible; Q921Y4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR030163; MFSD5.
DR InterPro; IPR008509; MOT2/MFSD5.
DR PANTHER; PTHR23516; PTHR23516; 1.
DR PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR Pfam; PF05631; MFS_5; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..450
FT /note="Molybdate-anion transporter"
FT /id="PRO_0000273402"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 49679 MW; 852010316FA08871 CRC64;
MLVTAYLSFV GLLASCLGLE LSRCRARPPG RACSNPSFLQ FQLDFYQVYF LALAADWLQA
PYLYKLYQHY HFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKKSCVL FSLTYSLCCI
TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV
LAVAAGVAAE AVASWIGLGP VAPFVAAIPL LALTGALALR NWGENYDRQR AFSKTCAGGL
RCLLSDRRVL LLGVIQALFE SVIFIFVFLW TPVLDPHGAP LGIVFSSFMA ASLLGSSLYR
IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQENP VESFIAFLLI ELACGLYFPS
MSFLRRKVIP ETEQAGVLNW FRVPLHLLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVTTL
LAVAGLFTVV RHDAELRVPS PTGEPYAPEL
