ID   MFSD5_PONAB             Reviewed;         450 AA.
AC   Q5R542; Q5R6V1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=MFSD5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR860382; CAH92509.1; -; mRNA.
DR   EMBL; CR861032; CAH93124.1; -; mRNA.
DR   RefSeq; NP_001126474.1; NM_001133002.1.
DR   AlphaFoldDB; Q5R542; -.
DR   SMR; Q5R542; -.
DR   STRING; 9601.ENSPPYP00000005216; -.
DR   GeneID; 100173461; -.
DR   KEGG; pon:100173461; -.
DR   CTD; 84975; -.
DR   eggNOG; KOG4332; Eukaryota.
DR   InParanoid; Q5R542; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..450
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273403"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        41
FT                   /note="S -> F (in Ref. 1; CAH92509)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        268
FT                   /note="F -> S (in Ref. 1; CAH92509)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        325
FT                   /note="S -> P (in Ref. 1; CAH92509)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   450 AA;  49747 MW;  E40F80D79BF697A3 CRC64;
     MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR SQLDFYQVYF LALAADWLQA
     PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL
     TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPTEWIPAT FARAAFWNHV
     LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL
     RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIVFSSFMA ASLLGSSLYR
     IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS
     MSFLRRKVIP ETEQAGVLNW FRVPLHLLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL
     LAVVGLFTVV RHDAELRVPS PTEEPYAPEL