ID   MFSD5_TAKRU             Reviewed;         480 AA.
AC   Q1KKV8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=mfsd5;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ481667; ABF22436.1; -; Genomic_DNA.
DR   RefSeq; XP_003963205.1; XM_003963156.2.
DR   AlphaFoldDB; Q1KKV8; -.
DR   SMR; Q1KKV8; -.
DR   STRING; 31033.ENSTRUP00000015720; -.
DR   Ensembl; ENSTRUT00000056974; ENSTRUP00000053806; ENSTRUG00000021121.
DR   GeneID; 101078972; -.
DR   KEGG; tru:101078972; -.
DR   CTD; 84975; -.
DR   eggNOG; KOG4332; Eukaryota.
DR   GeneTree; ENSGT00390000012629; -.
DR   InParanoid; Q1KKV8; -.
DR   Proteomes; UP000005226; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..480
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273405"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   480 AA;  52988 MW;  46A82A915608C6D5 CRC64;
     MFVTAYFAVI SLLALCVGLE LTARRLTPPE SSAAVNPAFR RFQATFLRAY LLALWADWLQ
     GPYLYKLYRH YSFLESQIAI LYVCGLASCV LFAPFSGWLS QALGRRHMCI FFCLSYATCC
     LTKLSRDYFV LIVGRILGGL STSLLTTTFE SWYVHHHVEI HDFPKEWIPT TFTKAATWNH
     GLAVGAGLVA NLLAEWLHLG PVAPFLLAVP FLACCAWFVL TDWAKEEAEK SPEGIKQTLP
     LGTLNGGVTH LSARARFSRS CSDGLRCMLS DKRVMLLGGV QALFESVLYI FIFLWTPVLD
     PHGSPLGIVF SCFMAASMVG SLLFRVATST RYHLQPGHVL CVAVLMAFFS FFMLTFSTVP
     GQPRPHESFL AFLLLELACG LYFPALNFLQ GRIIPEEKRA SVLAWFRLPL HLLACLGLLA
     LHGEVSGTGA GETGSGTRHM FGGCAVMMLA ALMAVVSLFT LGRNDTDLKL EGSRGEGEMY