ID   MFSD5_XENLA             Reviewed;         451 AA.
AC   Q08B29;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=mfsd5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC124899; AAI24900.1; -; mRNA.
DR   RefSeq; NP_001121281.1; NM_001127809.1.
DR   AlphaFoldDB; Q08B29; -.
DR   SMR; Q08B29; -.
DR   DNASU; 100158364; -.
DR   GeneID; 100158364; -.
DR   KEGG; xla:100158364; -.
DR   CTD; 100158364; -.
DR   Xenbase; XB-GENE-967136; mfsd5.S.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100158364; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..451
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273406"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  50242 MW;  CD45A7548DB2A665 CRC64;
     MLVTAYLFLL GLLALWGVLE FSACHSKPSA SSNALGNPAF RQFQYDFYRT YFPALAADWL
     QGPYLYKLYQ HYHFLEGQIA IIYVCGFGAS VFAGLVSVPL TSRLGRRKSC ILFCLLLSAS
     YLCKLSQEYF VLMTGRVLGG FSSSLLFSCF EAWYTHEHAE QHDFPAEWLP HTFTRAAAWN
     GGIAIAAGIT ANVCAEWLGL GPASPSVLAV PLLVLSVVLV IREWDENYGQ TSSFRRVCGD
     GLRCLLRDRR VLLLGTIQAL FESVVYIFIF LWTPVLDPHN APLGIAFSSF MAASAVGSSL
     YHLATSKKYH LQPMHVLCLS ILMVFFSLFM LTFSTAPGQE HPTESLLAFL LIELACGLYF
     PAMRFLRRRL IPEKEQTGVL NWFRVPLNLL AGLGLLVLHD SDYQSGTRNM FSLCAVTMLL
     ALLCVVSLFT MVRNDSELRL PASEPEPNGT E