ID   MFSD5_XENTR             Reviewed;         452 AA.
AC   Q28E13;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Molybdate-anion transporter;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 5;
DE   AltName: Full=Molybdate transporter 2 homolog;
GN   Name=mfsd5; ORFNames=TEgg028j23.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates high-affinity intracellular uptake of the rare
CC       oligo-element molybdenum. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR848498; CAJ82274.1; -; mRNA.
DR   RefSeq; NP_001015939.1; NM_001015939.2.
DR   AlphaFoldDB; Q28E13; -.
DR   SMR; Q28E13; -.
DR   STRING; 8364.ENSXETP00000027721; -.
DR   TCDB; 2.A.1.40.3; the major facilitator superfamily (mfs).
DR   PaxDb; Q28E13; -.
DR   Ensembl; ENSXETT00000027721; ENSXETP00000027721; ENSXETG00000012669.
DR   GeneID; 548693; -.
DR   KEGG; xtr:548693; -.
DR   CTD; 84975; -.
DR   Xenbase; XB-GENE-967131; mfsd5.
DR   eggNOG; KOG4332; Eukaryota.
DR   HOGENOM; CLU_034007_2_0_1; -.
DR   InParanoid; Q28E13; -.
DR   OMA; FPISIMF; -.
DR   OrthoDB; 565504at2759; -.
DR   PhylomeDB; Q28E13; -.
DR   TreeFam; TF328562; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012669; Expressed in egg cell and 12 other tissues.
DR   ExpressionAtlas; Q28E13; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015098; F:molybdate ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR030163; MFSD5.
DR   InterPro; IPR008509; MOT2/MFSD5.
DR   PANTHER; PTHR23516; PTHR23516; 1.
DR   PANTHER; PTHR23516:SF14; PTHR23516:SF14; 1.
DR   Pfam; PF05631; MFS_5; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..452
FT                   /note="Molybdate-anion transporter"
FT                   /id="PRO_0000273407"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  50195 MW;  15492FDDE06EEB86 CRC64;
     MLLTAYFVLV GLIALWAVLE FSACHSKPST SSNAVGNPAF RQFQYDFYRT YFPALAADWL
     QGPYLYKLYQ HYHFLEGQIA IIYVCGFGAS VFAGLVSAPL TSRLGRRKSC ILFCLLLSAS
     YLCKLSQEYF VLITGRVLGG FSSSLLFSSF EAWYTHEHAE QHDFPAEWLP HTFTRAAAWN
     GGIAIAAGVI ANACAEWLGL GPASPSVLAV PLLVLSVALV IREWDENYGQ TSSFRRVCGD
     GLRCLLRDRR VLLLGTIQAL FESVVYIFIF LWTPVLDPHN TPLGIAFSSF MAASAAGSSL
     YRLATSKKYH LQPMHVLCLS ILMVFFSLFM LTFSTAPGQE HPTESLLAFL LIELACGLYF
     PAMGFLRCRL IPEKEQIGVL NWFRVPLNLL AGLGLLVLHD SDYQSGTRNM FSLCAITMLL
     ALLCVVSLFT MVRNDSELRL PTSETEPNGT EQ