ID   MFSD6_PIG               Reviewed;         798 AA.
AC   A1DWM3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 6;
DE   AltName: Full=Macrophage MHC class I receptor 2 homolog;
GN   Name=MFSD6; Synonyms=MMR2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bone D.B.J., Hammond J.R.;
RT   "Identification of the pig ortholog of hUPP1 in PK15 cells.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC       {ECO:0000305}.
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DR   EMBL; EF065517; ABK96919.1; -; mRNA.
DR   RefSeq; NP_001090926.1; NM_001097457.1.
DR   RefSeq; XP_005672087.1; XM_005672030.2.
DR   RefSeq; XP_005672088.1; XM_005672031.2.
DR   AlphaFoldDB; A1DWM3; -.
DR   STRING; 9823.ENSSSCP00000017005; -.
DR   PaxDb; A1DWM3; -.
DR   PeptideAtlas; A1DWM3; -.
DR   PRIDE; A1DWM3; -.
DR   Ensembl; ENSSSCT00005021671; ENSSSCP00005012944; ENSSSCG00005013876.
DR   Ensembl; ENSSSCT00045042492; ENSSSCP00045029507; ENSSSCG00045024719.
DR   Ensembl; ENSSSCT00070017651; ENSSSCP00070014638; ENSSSCG00070009097.
DR   GeneID; 100037960; -.
DR   KEGG; ssc:100037960; -.
DR   CTD; 54842; -.
DR   eggNOG; KOG3762; Eukaryota.
DR   HOGENOM; CLU_013133_2_0_1; -.
DR   InParanoid; A1DWM3; -.
DR   OrthoDB; 628784at2759; -.
DR   TreeFam; TF314366; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 15.
DR   Genevisible; A1DWM3; SS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 3.
DR   InterPro; IPR024989; MFS_assoc_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF12832; MFS_1_like; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..798
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 6"
FT                   /id="PRO_0000321942"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        553..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        588..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        614..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          25..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          671..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..692
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        755..780
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         11
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZSS7"
SQ   SEQUENCE   798 AA;  88389 MW;  5ACEC180ACFFEB30 CRC64;
     MATDDKVAIL TDDEEEQKRK YVLADPFNGI SREPEPPSNE TPSPSESAAI PEEETDWIEK
     HCVKINNDLL ISKVFYFFFY SAYGSLYPLL PVYYKQLGMS PSQSGLLVGI RYFIEFCSAP
     FWGVVADRFK KGKVVLLFSL LCWVLFNLGI GFVKPATLRC VPKIPPTARP TNSSHPFTIL
     PANSSIVPSI TTSTRTREKR NLPPYDGLEM LVSEPNVTET VIFSTAPNKT SAPTLQPQTD
     EITDRVMDLT SHPSTAPSTP PGNTTRETTT SLVTTTKSLP SDQVTLVYDQ QEVEAIFLVI
     LVVVIIGEFF SASSVTIVDT VTLQYLGKHR DRYGLQRMWG SLGWGLAMLS VGIGIDYTHI
     DVLIDGKGCK PPEYRNYQIV FIVFGVLMTM ALIVATQFRF RYNHFKNGEN KGKEVEIPQV
     ERNSSTECSE ETPTTTSHSQ AFNFWDLIRL LCSVQYGSVL FVAWFMGFGY GFVFTFLYWH
     LEDLNGTTTL FGVCSVLSHV SELTAYFFSH KLIELIGHIR VLYIGLACNT ARYIYISYLE
     NAWTVLPMEV LQGVTHAAIW AACISYLSAA VPPELRTSAQ GILQGLHLGL GRGCGAMIGG
     VLVNYFGAAA TFRGIGMACL VILLLFALIQ WLAVPDEEED KTMLAERIPV PSSPVPIATI
     DLVQQQTEDV MPRIEPRLPP KKTKHQEEQE DVNKPAWGVS SSPWVTFVYA LYQIKEMMQL
     TRDNRASEIQ PLQGTSENRE SPPAGGGTLP GPCETHSDPS RNQPSPQAAA ASQTQSSPAR
     PRVEESEDQQ AQPAAGGH