MFSD8_XENLA
ID MFSD8_XENLA Reviewed; 510 AA.
AC Q6GPQ3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Major facilitator superfamily domain-containing protein 8;
GN Name=mfsd8;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a carrier that transport small solutes by using
CC chemiosmotic ion gradients. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Sorting to lysosomes involves
CC tyrosine- and/or dileucine-based motifs. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC073059; AAH73059.1; -; mRNA.
DR RefSeq; NP_001085636.1; NM_001092167.1.
DR AlphaFoldDB; Q6GPQ3; -.
DR SMR; Q6GPQ3; -.
DR DNASU; 444062; -.
DR GeneID; 444062; -.
DR KEGG; xla:444062; -.
DR CTD; 444062; -.
DR Xenbase; XB-GENE-998879; mfsd8.L.
DR OrthoDB; 685352at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 444062; Expressed in egg cell and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..510
FT /note="Major facilitator superfamily domain-containing
FT protein 8"
FT /id="PRO_0000311235"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..72
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..445
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 467..476
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 498..510
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 14..15
FT /note="Dileucine internalization motif"
FT /evidence="ECO:0000250"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 510 AA; 56163 MW; 5D877B380173E1AA CRC64;
MASIDDDDDE RTPLLQDSHI GELVETQKQL KSRWWSIRVM YLTMFLSSVG FSIVMTSIWP
YLQKVDQSAD ASFLGWVIAS FSLGQMVASP LFGLWSNHRP RREPLVVSIT ILVAASCLYA
YVHVPASHNK YYMLLARTFV GFGSGNVAVV RSYVAGATSL SERTGAMANI SAFQAMGFIL
GPAFQAALSV IGETGITING ISLQVNMYTA PALMGALLGI GNIILIFAIF REHRVDDLEK
NVSSINSESE VTDVEKANEG PIDQIAVISS NILFFVVLFV FAIFETISTP LTMDMYAWTR
TQAVFYNGII LAAVGVESVI VFLTVKILCK KTGERVLLLG GLAVIWIGFF ILLPWGNQMP
KIQWTDLQNA TIHNTTQWTS SIPSSGNHSV EPTGCPVIQT WCLYTPVIHL AQYLTSDILI
GVGYPICNVM SYTLYSKIIG PKPQGLYMGW LTAAGSAART LGPVFVSQIY THLGTRWTFG
IICAFVALSL LHLTAVYKRL IPFSTRYERL
