MFSD9_MOUSE
ID MFSD9_MOUSE Reviewed; 466 AA.
AC Q8C0T7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Major facilitator superfamily domain-containing protein 9;
GN Name=Mfsd9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AK029874; BAC26653.1; -; mRNA.
DR EMBL; BC057633; AAH57633.1; -; mRNA.
DR CCDS; CCDS14915.1; -.
DR RefSeq; NP_766087.1; NM_172499.2.
DR AlphaFoldDB; Q8C0T7; -.
DR SMR; Q8C0T7; -.
DR STRING; 10090.ENSMUSP00000035727; -.
DR TCDB; 2.A.1.2.72; the major facilitator superfamily (mfs).
DR iPTMnet; Q8C0T7; -.
DR PhosphoSitePlus; Q8C0T7; -.
DR MaxQB; Q8C0T7; -.
DR PaxDb; Q8C0T7; -.
DR PRIDE; Q8C0T7; -.
DR ProteomicsDB; 292232; -.
DR Antibodypedia; 65316; 8 antibodies from 4 providers.
DR DNASU; 211798; -.
DR Ensembl; ENSMUST00000039672; ENSMUSP00000035727; ENSMUSG00000041945.
DR GeneID; 211798; -.
DR KEGG; mmu:211798; -.
DR UCSC; uc007auo.1; mouse.
DR CTD; 84804; -.
DR MGI; MGI:2443548; Mfsd9.
DR VEuPathDB; HostDB:ENSMUSG00000041945; -.
DR eggNOG; KOG2615; Eukaryota.
DR GeneTree; ENSGT00940000159390; -.
DR HOGENOM; CLU_001265_10_12_1; -.
DR InParanoid; Q8C0T7; -.
DR OMA; STFVGCW; -.
DR OrthoDB; 1090653at2759; -.
DR PhylomeDB; Q8C0T7; -.
DR TreeFam; TF314512; -.
DR BioGRID-ORCS; 211798; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mfsd9; mouse.
DR PRO; PR:Q8C0T7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8C0T7; protein.
DR Bgee; ENSMUSG00000041945; Expressed in secondary oocyte and 196 other tissues.
DR ExpressionAtlas; Q8C0T7; baseline and differential.
DR Genevisible; Q8C0T7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..466
FT /note="Major facilitator superfamily domain-containing
FT protein 9"
FT /id="PRO_0000305026"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 466 AA; 49663 MW; 33E4C9D9C0671832 CRC64;
MALGVPGHGA SRQDLASETP VTATAPSSAV SSRRFLLWLY LVGFLDLFGV SMVVPLLNLH
VRSLGASPVV AGIVGSSYGV LQLFSSTFVG CWSDVVGRRS SLLVCILLSA LGYLLLGMST
NVFLFTLARV PVGVFKHTLS ISRALLSDLV TEKERPLVLG QFNTASGVGF ILGPVVGGYL
TELDGGFYVT AFICCSVFLL NAGLVWLLPW RETSLNIPDN GWSLDGKHTT EPIKSEGTLQ
GAATTSTARR SERTVQAPWV EVMLALKDMK NLIFSALWDV FLMRLLMGVA VMLYYSNFVL
ALEERFEVRP KTTGYLISYT SALGTLAGFA VGPILRLYKH NSYMVLLHSS VLTCLLLVVY
STTCSMAMVV FSSTLLSFST TIGRTCITDL QLSVGGAQAS GTVIGVGQSV TAVGRILAPL
LSGVAQEISP CGPPSLGAAL ALVAILIMTL NRPPFSGDGS ERLKQE
