ID   MFTR_MYCTO              Reviewed;         198 AA.
AC   P9WMB6; L0T674; P95037; Q7D9F1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Putative mycofactocin biosynthesis transcriptional regulator MftR;
GN   Name=mftR; OrderedLocusNames=MT0719;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: May regulate a gene cluster involved in mycofactocin
CC       expression. Mycofactocin is a conserved polypeptide that might serve as
CC       an electron carrier (By similarity). {ECO:0000250}.
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DR   EMBL; AE000516; AAK44946.1; -; Genomic_DNA.
DR   PIR; F70640; F70640.
DR   RefSeq; WP_003403482.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMB6; -.
DR   SMR; P9WMB6; -.
DR   EnsemblBacteria; AAK44946; AAK44946; MT0719.
DR   KEGG; mtc:MT0719; -.
DR   PATRIC; fig|83331.31.peg.767; -.
DR   HOGENOM; CLU_069356_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041347; MftR_C.
DR   InterPro; IPR023851; Tscrpt_reg_TetR-type.
DR   Pfam; PF17754; TetR_C_14; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR03968; mycofact_TetR; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..198
FT                   /note="Putative mycofactocin biosynthesis transcriptional
FT                   regulator MftR"
FT                   /id="PRO_0000427332"
FT   DOMAIN          12..72
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   198 AA;  22264 MW;  0167B32FB5687C2A CRC64;
     MPHESRVGRR RSTTPHHISD VAIELFAAHG FTDVSVDDIA RAAGIARRTL FRYYASKNAI
     PWGDFSTHLA QLQGLLDNID SRIQLRDALR AALLAFNTFD ESETIRHRKR MRVILQTPEL
     QAYSMTMYAG WREVIAKFVA RRSGGKTTDF MPQTVAWTML GVALSAYEHW LRDESVSLTE
     ALGAAFDVVG AGLDRLNQ