ID   MFTR_MYCTU              Reviewed;         198 AA.
AC   P9WMB7; L0T674; P95037; Q7D9F1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Putative mycofactocin biosynthesis transcriptional regulator MftR;
GN   Name=mftR; OrderedLocusNames=Rv0691c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21223593; DOI=10.1186/1471-2164-12-21;
RA   Haft D.H.;
RT   "Bioinformatic evidence for a widely distributed, ribosomally produced
RT   electron carrier precursor, its maturation proteins, and its
RT   nicotinoprotein redox partners.";
RL   BMC Genomics 12:21-21(2011).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May regulate a gene cluster involved in mycofactocin
CC       expression. Mycofactocin is a conserved polypeptide that might serve as
CC       an electron carrier.
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DR   EMBL; AL123456; CCP43434.1; -; Genomic_DNA.
DR   PIR; F70640; F70640.
DR   RefSeq; NP_215205.1; NC_000962.3.
DR   RefSeq; WP_003403482.1; NZ_NVQJ01000007.1.
DR   AlphaFoldDB; P9WMB7; -.
DR   SMR; P9WMB7; -.
DR   STRING; 83332.Rv0691c; -.
DR   PaxDb; P9WMB7; -.
DR   DNASU; 888296; -.
DR   GeneID; 888296; -.
DR   KEGG; mtu:Rv0691c; -.
DR   TubercuList; Rv0691c; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; VMYEGWR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041347; MftR_C.
DR   InterPro; IPR023851; Tscrpt_reg_TetR-type.
DR   Pfam; PF17754; TetR_C_14; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR03968; mycofact_TetR; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..198
FT                   /note="Putative mycofactocin biosynthesis transcriptional
FT                   regulator MftR"
FT                   /id="PRO_0000415280"
FT   DOMAIN          12..72
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   198 AA;  22264 MW;  0167B32FB5687C2A CRC64;
     MPHESRVGRR RSTTPHHISD VAIELFAAHG FTDVSVDDIA RAAGIARRTL FRYYASKNAI
     PWGDFSTHLA QLQGLLDNID SRIQLRDALR AALLAFNTFD ESETIRHRKR MRVILQTPEL
     QAYSMTMYAG WREVIAKFVA RRSGGKTTDF MPQTVAWTML GVALSAYEHW LRDESVSLTE
     ALGAAFDVVG AGLDRLNQ