ID   MG101_KLULA             Reviewed;         262 AA.
AC   Q00970; Q6CWI9;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mitochondrial genome maintenance protein MGM101;
DE   Flags: Precursor;
GN   Name=MGM101; OrderedLocusNames=KLLA0B03740g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   PubMed=8917319; DOI=10.1007/bf02173982;
RA   Clark-Walker G.D., Chen X.J.;
RT   "A vital function for mitochondrial DNA in the petite-negative yeast
RT   Kluyveromyces lactis.";
RL   Mol. Gen. Genet. 252:746-750(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Performs an essential function in the repair of oxidatively
CC       damaged mtDNA that is required for the maintenance of the mitochondrial
CC       genome. Binds to DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MGM101 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U43558; AAA86264.1; -; Genomic_DNA.
DR   EMBL; CR382122; CAH02093.1; -; Genomic_DNA.
DR   PIR; S72480; S72480.
DR   RefSeq; XP_451700.1; XM_451700.1.
DR   AlphaFoldDB; Q00970; -.
DR   STRING; 28985.XP_451700.1; -.
DR   EnsemblFungi; CAH02093; CAH02093; KLLA0_B03740g.
DR   GeneID; 2897086; -.
DR   KEGG; kla:KLLA0_B03740g; -.
DR   eggNOG; ENOG502RXU4; Eukaryota.
DR   HOGENOM; CLU_028692_1_0_1; -.
DR   InParanoid; Q00970; -.
DR   OMA; TKIWTRK; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0000262; C:mitochondrial chromosome; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblFungi.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0000725; P:recombinational repair; IEA:EnsemblFungi.
DR   InterPro; IPR009446; Mgm101.
DR   PANTHER; PTHR31404; PTHR31404; 1.
DR   Pfam; PF06420; Mgm101p; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Mitochondrion; Mitochondrion nucleoid;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..262
FT                   /note="Mitochondrial genome maintenance protein MGM101"
FT                   /id="PRO_0000021718"
FT   CONFLICT        201
FT                   /note="C -> S (in Ref. 1; AAA86264)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   262 AA;  29000 MW;  530B846436162F0C CRC64;
     MLGFRHVIRA TSKRFATSGT SMVRKTVTSG NSNAIRSATS NVVPPASSAA AASAPSTIKR
     VPGYNKTLED SLNGTILENP VETQATQSSN EINWYTSYHG IGSKPFSDET QNALSSALNA
     DDIEIKPDGL IYLPEIKYRR ILNKAFGPGG WGLVPRSETI VTAKLVTREY ALVCHGQMVS
     IARGEQDYFS ETGIPTATEG CKSNALMRCC KDLGIGSELW DPVFIKQYKK KHCTEKFVEH
     VTTKKKKKIW LRKDREVEYP YK