ID   MG101_SCHPO             Reviewed;         270 AA.
AC   O14354;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Mitochondrial genome maintenance protein mgm101;
DE   Flags: Precursor;
GN   Name=mgm101; ORFNames=SPBC30D10.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Performs an essential function in the repair of oxidatively
CC       damaged mtDNA that is required for the maintenance of the mitochondrial
CC       genome. Binds to DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the MGM101 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB10803.2; -; Genomic_DNA.
DR   PIR; T40188; T40188.
DR   RefSeq; NP_596277.2; NM_001022198.2.
DR   AlphaFoldDB; O14354; -.
DR   BioGRID; 276802; 3.
DR   STRING; 4896.SPBC30D10.08.1; -.
DR   iPTMnet; O14354; -.
DR   MaxQB; O14354; -.
DR   PaxDb; O14354; -.
DR   EnsemblFungi; SPBC30D10.08.1; SPBC30D10.08.1:pep; SPBC30D10.08.
DR   GeneID; 2540271; -.
DR   KEGG; spo:SPBC30D10.08; -.
DR   PomBase; SPBC30D10.08; mgm101.
DR   VEuPathDB; FungiDB:SPBC30D10.08; -.
DR   eggNOG; ENOG502RXU4; Eukaryota.
DR   HOGENOM; CLU_028692_1_1_1; -.
DR   InParanoid; O14354; -.
DR   OMA; TKIWTRK; -.
DR   PRO; PR:O14354; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000262; C:mitochondrial chromosome; ISO:PomBase.
DR   GO; GO:0042645; C:mitochondrial nucleoid; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0036297; P:interstrand cross-link repair; IBA:GO_Central.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IC:PomBase.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IBA:GO_Central.
DR   GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR   InterPro; IPR009446; Mgm101.
DR   PANTHER; PTHR31404; PTHR31404; 1.
DR   Pfam; PF06420; Mgm101p; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Mitochondrion; Mitochondrion nucleoid;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..35
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..270
FT                   /note="Mitochondrial genome maintenance protein mgm101"
FT                   /id="PRO_0000045818"
SQ   SEQUENCE   270 AA;  31179 MW;  32DC2DF9EB7A45E9 CRC64;
     MQTMLGKPAL QYFGKLSRYL YKNGEPINIW VYSRNSSFSV IPKNGLLSPK ITQRFYQNSS
     IQYQKDKNIY EPKENLEEKE LSEGFLDESR LEIPEAGHNW EKSFFGLSSQ PFSKEICDLL
     TAPLEVDDIE IKPDGILYLP EIKYRRILNK AFGPGGWGLA PRGNTNVTSK SVSREYALVC
     HGRLVSVARG EQTYFDPEGI ATASEGCKSN ALMRCCKDLG VASELWDPRY IRVFKRENCV
     EVFVENVLTK KRRKLWRRKE DKFSYPYKEV