MGA1_YEAST
ID MGA1_YEAST Reviewed; 456 AA.
AC P53050; D6VV29;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein MGA1;
GN Name=MGA1; OrderedLocusNames=YGR249W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=D416-1-4;
RA Wada H.;
RL Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9133742;
RX DOI=10.1002/(sici)1097-0061(19970330)13:4<373::aid-yea82>3.0.co;2-v;
RA Feroli F., Carignani G., Pavanello A., Guerreiro P., Azevedo D.,
RA Rodrigues-Pousada C., Melchioretto P., Panzeri L., Agostoni Carbone M.L.;
RT "Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII
RT reveals the presence of eight open reading frames, including BRF1
RT (TFIIIB70) and GCN5 genes.";
RL Yeast 13:373-377(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D29626; BAA06105.1; -; Genomic_DNA.
DR EMBL; Y07703; CAA68970.1; -; Genomic_DNA.
DR EMBL; Z73034; CAA97278.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08340.1; -; Genomic_DNA.
DR PIR; S47924; S47924.
DR RefSeq; NP_011765.1; NM_001181378.1.
DR AlphaFoldDB; P53050; -.
DR SMR; P53050; -.
DR BioGRID; 33500; 69.
DR DIP; DIP-4232N; -.
DR IntAct; P53050; 4.
DR STRING; 4932.YGR249W; -.
DR MaxQB; P53050; -.
DR PaxDb; P53050; -.
DR PRIDE; P53050; -.
DR EnsemblFungi; YGR249W_mRNA; YGR249W; YGR249W.
DR GeneID; 853164; -.
DR KEGG; sce:YGR249W; -.
DR SGD; S000003481; MGA1.
DR VEuPathDB; FungiDB:YGR249W; -.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_034478_1_0_1; -.
DR InParanoid; P53050; -.
DR OMA; QLESKWM; -.
DR BioCyc; YEAST:G3O-30922-MON; -.
DR PRO; PR:P53050; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53050; protein.
DR GO; GO:0000785; C:chromatin; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..456
FT /note="Protein MGA1"
FT /id="PRO_0000124593"
FT DNA_BIND 3..118
FT /evidence="ECO:0000250"
FT REGION 229..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 50735 MW; 48A21F0D89749BA6 CRC64;
MQPKTFVHQL HAILLEPEVN KWIYWSPTDN TVFFLKPYDP NFSTHVLKRY FKHGNVNSFV
RQLHMYGFHK LSHPSPDQSS ANNGNVKELV EWKFTHPSGF FFKEANAGIL NKIQRKSTGV
GKDGKRKNIL SPISVSYVDA SRLNVLSQQS GPVSAREPSN MFMGSPVHYS TSQSPPHISI
PQQQQSSGPY LISSLPPQQP TVNMMRRQSI SARMMNSYDY PNQFSTQDSI VQPQQPQQVL
SPQALSGPPM KKSGTLSSTD DLKTTSLPIV NYPMPYHPGA FAQQQQQQQQ PLPTVPPYSS
YSTPFPSMMN SLSNSASNSP ALGVCNNNVT LPKKSNISER QALDNHIQTL KNSLSTITDL
IEKHINSASQ DENKTLTNDA MNKDLRTSLS LLQNSKEEII QLESKWMSMQ SVKTTALPLQ
ETTNTSSTLT SLTSSIIPKS IPIITKGEVA TKPASY
