ID   MGF_CHICK               Reviewed;         201 AA.
AC   P13854;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Myelomonocytic growth factor;
DE            Short=MGF;
DE   Flags: Precursor;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2785450; DOI=10.1002/j.1460-2075.1989.tb03362.x;
RA   Leutz A., Damm K., Sterneck E., Kowenz E., Ness S., Frank R., Gausepohl H.,
RA   Pan Y.-C.E., Smart J., Hayman M., Graf T.;
RT   "Molecular cloning of the chicken myelomonocytic growth factor (cMGF)
RT   reveals relationship to interleukin 6 and granulocyte colony stimulating
RT   factor.";
RL   EMBO J. 8:175-181(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1549124; DOI=10.1128/mcb.12.4.1728-1735.1992;
RA   Sterneck E., Blattner C., Graf T., Leutz A.;
RT   "Structure of the chicken myelomonocytic growth factor gene and specific
RT   activation of its promoter in avian myelomonocytic cells by protein
RT   kinases.";
RL   Mol. Cell. Biol. 12:1728-1735(1992).
CC   -!- FUNCTION: Hematopoietic growth factor that stimulates the proliferation
CC       and colony formation of normal and transformed avian cells of the
CC       myeloid lineage.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; M85034; AAA48694.1; -; Genomic_DNA.
DR   EMBL; X14477; CAA32639.1; -; mRNA.
DR   PIR; A42247; A42247.
DR   RefSeq; NP_990610.1; NM_205279.1.
DR   AlphaFoldDB; P13854; -.
DR   SMR; P13854; -.
DR   STRING; 9031.ENSGALP00000042841; -.
DR   Ensembl; ENSGALT00000058288; ENSGALP00000044330; ENSGALG00000030907.
DR   GeneID; 396216; -.
DR   KEGG; gga:396216; -.
DR   CTD; 1440; -.
DR   VEuPathDB; HostDB:geneid_396216; -.
DR   eggNOG; ENOG502SCNA; Eukaryota.
DR   GeneTree; ENSGT00390000017328; -.
DR   HOGENOM; CLU_118367_0_0_1; -.
DR   OMA; HHQVGGF; -.
DR   OrthoDB; 1289639at2759; -.
DR   PhylomeDB; P13854; -.
DR   Reactome; R-GGA-449836; Other interleukin signaling.
DR   Reactome; R-GGA-9674555; Signaling by CSF3 (G-CSF).
DR   Reactome; R-GGA-9705462; Inactivation of CSF3 (G-CSF) signaling.
DR   PRO; PR:P13854; -.
DR   Proteomes; UP000000539; Chromosome 27.
DR   Bgee; ENSGALG00000030907; Expressed in liver and 1 other tissue.
DR   ExpressionAtlas; P13854; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..201
FT                   /note="Myelomonocytic growth factor"
FT                   /id="PRO_0000015596"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        61..67
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..99
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   201 AA;  22374 MW;  240A8DD21B4244E6 CRC64;
     MCCLTPVLAL ALVLGAPWQA LHGAPLAELS GDHDFQLFLH KNLEFTRKIR GDVAALQRAV
     CDTFQLCTEE ELQLVQPDPH LVQAPLDQCH KRGFQAEVCF TQIRAGLHAY HDSLGAVLRL
     LPNHTTLVET LQLDAANLSS NIQQQMEDLG LDTVTLPAEQ RSPPPTFSGP FQQQVGGFFI
     LANFQRFLET AYRALRHLAR L