ID   MGLA1_PHOPR             Reviewed;         497 AA.
AC   Q6LK34;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA 1 {ECO:0000255|HAMAP-Rule:MF_01717};
DE            EC=7.5.2.11 {ECO:0000255|HAMAP-Rule:MF_01717};
GN   Name=mglA1 {ECO:0000255|HAMAP-Rule:MF_01717}; OrderedLocusNames=PBPRB0473;
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9;
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex MglABC involved in
CC       galactose/methyl galactoside import. Responsible for energy coupling to
CC       the transport system. {ECO:0000255|HAMAP-Rule:MF_01717}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.5.2.11; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01717};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MglA),
CC       two transmembrane proteins (MglC) and a solute-binding protein (MglB).
CC       {ECO:0000255|HAMAP-Rule:MF_01717}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01717}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01717}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01717}.
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DR   EMBL; CR378676; CAG22346.1; -; Genomic_DNA.
DR   RefSeq; WP_011220555.1; NC_006371.1.
DR   AlphaFoldDB; Q6LK34; -.
DR   SMR; Q6LK34; -.
DR   STRING; 298386.PBPRB0473; -.
DR   PRIDE; Q6LK34; -.
DR   EnsemblBacteria; CAG22346; CAG22346; PBPRB0473.
DR   KEGG; ppr:PBPRB0473; -.
DR   eggNOG; COG1129; Bacteria.
DR   HOGENOM; CLU_000604_92_3_6; -.
DR   OMA; EGMAVIM; -.
DR   OrthoDB; 551294at2; -.
DR   Proteomes; UP000000593; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR   PROSITE; PS51260; MGLA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW   Translocase; Transport.
FT   CHAIN           1..497
FT                   /note="Galactose/methyl galactoside import ATP-binding
FT                   protein MglA 1"
FT                   /id="PRO_0000261371"
FT   DOMAIN          6..243
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT   DOMAIN          256..494
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
SQ   SEQUENCE   497 AA;  55487 MW;  4F68ACE6E722CB12 CRC64;
     MNQVLLEMRG ITKTFPGVKA LDNVQLTLKK GRVMALMGEN GAGKSTLMKV LFGIYQRDCG
     TIRYQGEQVN YSGAKEALEA GVSMIHQELS PILHRSIAEN IWLGREPLKG PLRLIDHAKM
     YRDTTELLKK LDLHLDPRTP MSELTVATMQ MIEISKAISY NSKIIIMDEP TSALTGKEVD
     HLFEIIEKLK KQGVSIVYIS HKMDEIFRIC DDITVFRDGC YIGEREAQNT NHDELVQMMV
     GRDLGDVFPP PTAKPGKVRL EVKNLSVEGV FDNISFKLHE GEILGIAGLV GAGRTELIET
     LFGVRKHDVG EIWINGENVE IKTPQDAISH KMAFLTEDRR QSGLYLMLDI FANTSIAHLD
     AYRNKVVNVL DVRSMQKDCA SQCTKLKVKT PGMAEKIDNL SGGNQQKVLL ARWMLTKPDI
     LFLDEPTRGI DIGAKSEIYK LMRLLTGMGK SLVMISSELP EVIGMSDRIL VMHGGKLKGE
     LDGKDASQQQ VMSMAFN