ID   MGLA2_PHOPR             Reviewed;         503 AA.
AC   Q6LG59;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA 2 {ECO:0000255|HAMAP-Rule:MF_01717};
DE            EC=7.5.2.11 {ECO:0000255|HAMAP-Rule:MF_01717};
GN   Name=mglA2 {ECO:0000255|HAMAP-Rule:MF_01717}; OrderedLocusNames=PBPRB1871;
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9;
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex MglABC involved in
CC       galactose/methyl galactoside import. Responsible for energy coupling to
CC       the transport system. {ECO:0000255|HAMAP-Rule:MF_01717}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.5.2.11; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01717};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MglA),
CC       two transmembrane proteins (MglC) and a solute-binding protein (MglB).
CC       {ECO:0000255|HAMAP-Rule:MF_01717}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01717}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01717}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01717}.
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DR   EMBL; CR378680; CAG23721.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6LG59; -.
DR   SMR; Q6LG59; -.
DR   STRING; 298386.PBPRB1871; -.
DR   EnsemblBacteria; CAG23721; CAG23721; PBPRB1871.
DR   KEGG; ppr:PBPRB1871; -.
DR   eggNOG; COG1129; Bacteria.
DR   HOGENOM; CLU_000604_92_3_6; -.
DR   Proteomes; UP000000593; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043211; F:ABC-type carbohydrate transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015862; ABC_transpr_MglA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43790:SF7; PTHR43790:SF7; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR   PROSITE; PS51260; MGLA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW   Translocase; Transport.
FT   CHAIN           1..503
FT                   /note="Galactose/methyl galactoside import ATP-binding
FT                   protein MglA 2"
FT                   /id="PRO_0000261372"
FT   DOMAIN          11..246
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT   DOMAIN          257..503
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT   BINDING         43..50
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
SQ   SEQUENCE   503 AA;  56245 MW;  A7CCD3C3EF0BA678 CRC64;
     MTTINKNEFL LEMTGISKEF PGVKALDKVN LKVRPHSIHA LMGENGAGKS TLLKCLFGIY
     EKNEGDIVFL GKSINFSSSK EALEAGVSMV HQELNQVLQR TVMDNIWLGR YPTKGFFVDQ
     KKMYEETKKV FEELDIDIDP NVKVATLSVS QMQMLEIAKA FSYDAKIVIM DEPTSSLTEK
     EVNHLFKIIK KLKEKGCGIV YISHKMEEIF EICDEITILR DGIWVDTRPL EGLTMDQIIG
     MMVGRELTQR FPEKTNTPKE TILAVKNLTA LNQPSVNDVS FELRKGEILG IAGLVGAKRT
     DIVETLFGIR ERSSGDIILH GKHLKNKDAH EAINNGFALV TEERRSTGIY SNLDITFNSL
     VANVEQYKEG FGLLSNRKMK SDTQWVIDAM SVKTPSHKTM IGSLSGGNQQ KIIIGRWLLT
     GPEILMLDEP TRGIDVGAKF EIYQLILELA NKDKGIIIIS SEMPELLGIT DRILVMSNGR
     AAGIVETKNT TQNEILSLAS RYL