MGLA_HAEIN
ID MGLA_HAEIN Reviewed; 506 AA.
AC P44884;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA {ECO:0000255|HAMAP-Rule:MF_01717};
DE EC=7.5.2.11 {ECO:0000255|HAMAP-Rule:MF_01717};
GN Name=mglA {ECO:0000255|HAMAP-Rule:MF_01717}; OrderedLocusNames=HI_0823;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Part of the ABC transporter complex MglABC involved in
CC galactose/methyl galactoside import. Responsible for energy coupling to
CC the transport system. {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.5.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01717};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MglA),
CC two transmembrane proteins (MglC) and a solute-binding protein (MglB).
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01717}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01717}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
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DR EMBL; L42023; AAC22482.1; -; Genomic_DNA.
DR PIR; H64096; H64096.
DR RefSeq; NP_438983.1; NC_000907.1.
DR RefSeq; WP_005652432.1; NC_000907.1.
DR AlphaFoldDB; P44884; -.
DR SMR; P44884; -.
DR STRING; 71421.HI_0823; -.
DR DNASU; 949835; -.
DR EnsemblBacteria; AAC22482; AAC22482; HI_0823.
DR KEGG; hin:HI_0823; -.
DR PATRIC; fig|71421.8.peg.864; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_6; -.
DR OMA; IKMLSGA; -.
DR PhylomeDB; P44884; -.
DR BioCyc; HINF71421:G1GJ1-864-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043211; F:ABC-type carbohydrate transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015862; ABC_transpr_MglA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43790:SF7; PTHR43790:SF7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51260; MGLA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..506
FT /note="Galactose/methyl galactoside import ATP-binding
FT protein MglA"
FT /id="PRO_0000092515"
FT DOMAIN 14..249
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT DOMAIN 260..506
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT BINDING 46..53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
SQ SEQUENCE 506 AA; 56568 MW; E00C133D72941FD5 CRC64;
MTAQTQCQDS QVLLTMTNVC KSFPGVKALD NANLTVRSHS VHALMGENGA GKSTLLKCLF
GIYAKDEGEI LFLGEPVNFK TSKEALENGI SMVHQELNLV RQTSVMDNLW LGRYPLKGPF
VDHAKMYRDT KAIFDELDID VDPKEKVAKL SVSQMQMIEI AKAFSYNAKI VIMDEPTSSL
SEKEVEHLFK IIDKLKQRGC GIIYISHKMD EIFKICDEIT ILRDGKWINT VNVKESTMEQ
IVGMMVGREL TQRFPEKTNV PKEVILQVEN LTAKNQPSIQ DVSFELRKGE ILGIAGLVGA
KRTDIVEAIF GVRELIEGTI KLHGKTVKNH TALEAINNGF ALVTEERRST GIYSNLSIEF
NSLISNMKSY LTPWKLLSTK KMKSDTQWVI DSMNVKTPSH RTTIGSLSGG NQQKVIIGRW
LLTQPEILML DEPTRGIDIG AKFEIYQLIQ ELAKKDKGII MISSEMPELL GVTDRILVMS
NGKLAGIVES AKTSQEEILQ LAAKYL
