MGLA_TREDE
ID MGLA_TREDE Reviewed; 497 AA.
AC Q73KK2; Q9ZGA2;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA {ECO:0000255|HAMAP-Rule:MF_01717};
DE EC=7.5.2.11 {ECO:0000255|HAMAP-Rule:MF_01717};
GN Name=mglA {ECO:0000255|HAMAP-Rule:MF_01717}; OrderedLocusNames=TDE_2216;
OS Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS / KCTC 15104).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243275;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX PubMed=11328650; DOI=10.3109/10425170009033992;
RA Lepine G., Ellen R.P.;
RT "MglA and mglB of Treponema denticola; similarity to ABC transport and spa
RT genes.";
RL DNA Seq. 11:419-431(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT "Comparison of the genome of the oral pathogen Treponema denticola with
RT other spirochete genomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC -!- FUNCTION: Part of the ABC transporter complex MglABC involved in
CC galactose/methyl galactoside import. Responsible for energy coupling to
CC the transport system. {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.5.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01717};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MglA),
CC two transmembrane proteins (MglC) and a solute-binding protein (MglB).
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01717}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01717}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF082511; AAD05298.1; -; Genomic_DNA.
DR EMBL; AE017226; AAS12735.1; -; Genomic_DNA.
DR RefSeq; NP_972816.1; NC_002967.9.
DR RefSeq; WP_002680067.1; NC_002967.9.
DR AlphaFoldDB; Q73KK2; -.
DR SMR; Q73KK2; -.
DR STRING; 243275.TDE_2216; -.
DR EnsemblBacteria; AAS12735; AAS12735; TDE_2216.
DR GeneID; 2739492; -.
DR KEGG; tde:TDE_2216; -.
DR PATRIC; fig|243275.7.peg.2093; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_12; -.
DR OMA; AKREIYQ; -.
DR OrthoDB; 551294at2; -.
DR BRENDA; 7.5.2.11; 6426.
DR Proteomes; UP000008212; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043211; F:ABC-type carbohydrate transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015862; ABC_transpr_MglA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43790:SF7; PTHR43790:SF7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51260; MGLA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..497
FT /note="Galactose/methyl galactoside import ATP-binding
FT protein MglA"
FT /id="PRO_0000261376"
FT DOMAIN 6..241
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT DOMAIN 252..497
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT CONFLICT 299
FT /note="E -> G (in Ref. 1; AAD05298)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 497 AA; 55284 MW; D70DFF1DA2EF0500 CRC64;
MSDVVLEIKN LSKSFGKNKV LDGINLTVRQ GSVMGLMGEN GAGKSTMMKC LFGIYTRDEG
AISLLNKSIE FKNPKEALES GVAMVHQELN LCLDRTVTDN LFLGRYPTNF GIVDEIKMFE
SASSLFSSLN MNVNPKTIMR TMSVSQRQMV EIAKAVSYNA KLIVLDEPTS SLTEREVKKL
FSIIRALQKK GVSFIYISHK MDEVFEVCDE VAVLRDGKMI LSKPVAGTNM NEIISAMVGR
SLDKRFPDVD NVPGEDFLKI ENLKTKYAPV LEDISFTVRK GEILGLYGLV GAGRSELLEA
LFGIRTIESG SISINDKYLK FKSSKEAMAH GFALLTEERK LNGMFGKDTI EFNTVITNLN
NYKTIGVLSK RKIREAANRE IETMRTRCLS ADQGISALSG GNQQKVIIGK WLERSPDVFL
MDEPTRGIDV GAKYEIYQLI IKMAKEGKTI IVVSSEMPEI LGITNRIAVM SNRRLAGIVN
TKETDQETLL RLSAKYL
