MGLA_TREPA
ID MGLA_TREPA Reviewed; 496 AA.
AC Q56342; Q56341;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA {ECO:0000255|HAMAP-Rule:MF_01717};
DE EC=7.5.2.11 {ECO:0000255|HAMAP-Rule:MF_01717};
GN Name=mglA {ECO:0000255|HAMAP-Rule:MF_01717}; OrderedLocusNames=TP_0685;
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=8988365; DOI=10.3109/10425179609020876;
RA Stamm L.V., Young N.R., Frye J.G., Hardham J.M.;
RT "Identification and sequences of the Treponema pallidum mglA and mglC
RT genes.";
RL DNA Seq. 6:293-298(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8921855; DOI=10.1016/0378-1119(96)00286-7;
RA Porcella S.F., Popova T.G., Hagman K.E., Penn C.W., Radolf J.D.,
RA Norgard M.V.;
RT "A mgl-like operon in Treponema pallidum, the syphilis spirochete.";
RL Gene 177:115-121(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- FUNCTION: Part of the ABC transporter complex MglABC involved in
CC galactose/methyl galactoside import. Responsible for energy coupling to
CC the transport system. {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.5.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01717};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MglA),
CC two transmembrane proteins (MglC) and a solute-binding protein (MglB).
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01717}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01717}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
CC {ECO:0000255|HAMAP-Rule:MF_01717}.
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DR EMBL; U45323; AAC44749.1; -; Genomic_DNA.
DR EMBL; U48416; AAC44585.1; -; Genomic_DNA.
DR EMBL; AE000520; AAC65648.1; -; Genomic_DNA.
DR PIR; JC5170; JC5170.
DR RefSeq; WP_010882130.1; NC_021490.2.
DR AlphaFoldDB; Q56342; -.
DR SMR; Q56342; -.
DR IntAct; Q56342; 1.
DR STRING; 243276.TPANIC_0685; -.
DR EnsemblBacteria; AAC65648; AAC65648; TP_0685.
DR KEGG; tpa:TP_0685; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_12; -.
DR OMA; AKREIYQ; -.
DR OrthoDB; 551294at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043211; F:ABC-type carbohydrate transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015862; ABC_transpr_MglA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43790:SF7; PTHR43790:SF7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51260; MGLA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..496
FT /note="Galactose/methyl galactoside import ATP-binding
FT protein MglA"
FT /id="PRO_0000092518"
FT DOMAIN 5..240
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT DOMAIN 243..496
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01717"
FT CONFLICT 118
FT /note="F -> L (in Ref. 1; AAC44749)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 496 AA; 55191 MW; B6F63D53C5CD1411 CRC64;
MCDVLTIRDL SKSFARNRVL NGVNFRMGKG AVVGLMGENG AGKSTLMKCL FGMYAKDTGQ
ILVDGSPVDF QSPKEALENG VAMVHQELNQ CLDRTVMDNL FLGRYPARFG IVDEKRMFDD
SLTLFASLKM DVNPRAVMRS MSVSQRQMVE IAKAMSYNAK IIVLDEPTSS LTEREIVRLF
AIIRDLSKKG VAFIYISHKM DEIFQICSEV IVLRDGVLTL SQSIGEVEMS DLITAMVGRT
LDKRFPDADN TVGDDYLEIR GLSTRYAPQL RDISLSVKRG EIFGLYGLVG AGRSELLEAI
FGLRTIADGE ISLAGKKIRL KSSRDAMKLN FAFVPEERKL NGMFAKGSIE YNTTIANLPA
YKRYGLLSKK KLQEAAEREI KAMRVKCVSP SELISALSGG NQQKVIIGKW LERDPDVLLL
DEPTRGIDVG AKYEIYQLII RMAREGKTII VVSSEMPEIL GITNRIAVMS NYRLAGIVDT
KSTDQEALLR LSARYL
