MGLC_ECOLI
ID MGLC_ECOLI Reviewed; 336 AA.
AC P23200; Q2MAT1;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Galactoside transport system permease protein MglC;
GN Name=mglC; OrderedLocusNames=b2148, JW2135;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1719366; DOI=10.1007/bf00267469;
RA Hogg R.W., Voelker C., von Carlowitz I.;
RT "Nucleotide sequence and analysis of the mgl operon of Escherichia coli
RT K12.";
RL Mol. Gen. Genet. 229:453-459(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC galactoside. Probably responsible for the translocation of the
CC substrate across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR EMBL; M59444; AAA24171.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75209.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76625.1; -; Genomic_DNA.
DR PIR; C37277; C37277.
DR RefSeq; NP_416653.1; NC_000913.3.
DR RefSeq; WP_001275118.1; NZ_STEB01000002.1.
DR AlphaFoldDB; P23200; -.
DR BioGRID; 4259171; 6.
DR ComplexPortal; CPX-4341; Beta-methyl-D-galactoside/galactose ABC transporter complex.
DR STRING; 511145.b2148; -.
DR TCDB; 3.A.1.2.3; the atp-binding cassette (abc) superfamily.
DR jPOST; P23200; -.
DR PaxDb; P23200; -.
DR PRIDE; P23200; -.
DR EnsemblBacteria; AAC75209; AAC75209; b2148.
DR EnsemblBacteria; BAE76625; BAE76625; BAE76625.
DR GeneID; 66673956; -.
DR GeneID; 949039; -.
DR KEGG; ecj:JW2135; -.
DR KEGG; eco:b2148; -.
DR PATRIC; fig|1411691.4.peg.93; -.
DR EchoBASE; EB0589; -.
DR eggNOG; COG4211; Bacteria.
DR HOGENOM; CLU_028880_1_0_6; -.
DR InParanoid; P23200; -.
DR OMA; DWFKAFL; -.
DR PhylomeDB; P23200; -.
DR BioCyc; EcoCyc:MGLC-MON; -.
DR BioCyc; MetaCyc:MGLC-MON; -.
DR PRO; PR:P23200; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005354; F:galactose transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0015592; F:methylgalactoside transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0015757; P:galactose transmembrane transport; IMP:EcoCyc.
DR GO; GO:0015765; P:methylgalactoside transport; IMP:EcoCyc.
DR InterPro; IPR001851; ABC_transp_permease.
DR InterPro; IPR030158; MglC.
DR PANTHER; PTHR32196:SF18; PTHR32196:SF18; 1.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..336
FT /note="Galactoside transport system permease protein MglC"
FT /id="PRO_0000060106"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..52
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..180
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..256
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..305
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 336 AA; 35550 MW; 3199C101AFD4196D CRC64;
MSALNKKSFL TYLKEGGIYV VLLVLLAIII FQDPTFLSLL NLSNILTQSS VRIIIALGVA
GLIVTQGTDL SAGRQVGLAA VVAATLLQSM DNANKVFPEM ATMPIALVIL IVCAIGAVIG
LINGLIIAYL NVTPFITTLG TMIIVYGINS LYYDFVGASP ISGFDSGFST FAQGFVALGS
FRLSYITFYA LIAVAFVWVL WNKTRFGKNI FAIGGNPEAA KVSGVNVGLN LLMIYALSGV
FYAFGGMLEA GRIGSATNNL GFMYELDAIA ACVVGGVSFS GGVGTVIGVV TGVIIFTVIN
YGLTYIGVNP YWQYIIKGAI IIFAVALDSL KYARKK
