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MGLC_TREPA
ID   MGLC_TREPA              Reviewed;         531 AA.
AC   Q57321;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Galactoside transport system permease protein MglC homolog;
GN   Name=mglC; OrderedLocusNames=TP_0686;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=8921855; DOI=10.1016/0378-1119(96)00286-7;
RA   Porcella S.F., Popova T.G., Hagman K.E., Penn C.W., Radolf J.D.,
RA   Norgard M.V.;
RT   "A mgl-like operon in Treponema pallidum, the syphilis spirochete.";
RL   Gene 177:115-121(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=8988365; DOI=10.3109/10425179609020876;
RA   Stamm L.V., Young N.R., Frye J.G., Hardham J.M.;
RT   "Identification and sequences of the Treponema pallidum mglA and mglC
RT   genes.";
RL   DNA Seq. 6:293-298(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       galactoside. Probably responsible for the translocation of the
CC       substrate across the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR   EMBL; U48416; AAC44586.1; -; Genomic_DNA.
DR   EMBL; U45323; AAC44750.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65649.1; -; Genomic_DNA.
DR   PIR; JC5172; JC5172.
DR   RefSeq; WP_010882131.1; NC_021490.2.
DR   AlphaFoldDB; Q57321; -.
DR   IntAct; Q57321; 2.
DR   STRING; 243276.TPANIC_0686; -.
DR   EnsemblBacteria; AAC65649; AAC65649; TP_0686.
DR   GeneID; 57879211; -.
DR   KEGG; tpa:TP_0686; -.
DR   eggNOG; COG4211; Bacteria.
DR   HOGENOM; CLU_481395_0_0_12; -.
DR   OMA; DWFKAFL; -.
DR   OrthoDB; 1254678at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001851; ABC_transp_permease.
DR   InterPro; IPR030158; MglC.
DR   PANTHER; PTHR32196:SF18; PTHR32196:SF18; 1.
DR   Pfam; PF02653; BPD_transp_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..531
FT                   /note="Galactoside transport system permease protein MglC
FT                   homolog"
FT                   /id="PRO_0000060109"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   531 AA;  57875 MW;  B92EFA6BC8ABF299 CRC64;
     MRDRTQCVAV PTQAFNEILD QDGQLTAYAQ RLEQLRERGS HRVALLRGEL ARIRQDQVLG
     MPEKRVQVAA HRLKISEAQA VARQCKTEET QLVRKAVARV RGLFRDFDCS VRDAMREQRL
     LLKQVATVQH TSASSDQREH CLAQLRQCKE ARHHAYRSLV EKSAALRNGK MTFIERVVRA
     LREYSFNFDA TQFFLANGLY IAIAVFFIAC IVVAPFSGNG NLLTIPNILT ILEQSSVRMF
     YAVGVAGIIL LAGTDLSIGR MVAMGSVVTG IILHPGQNIV TFFGLGPWDF TPVPMAVRVV
     MSLAVSVALC VSFSLFAGFF SARLKIHPFI STLATQLIIY GVLFFGTSGT PVGSIDPYIK
     DLFGGRWILG TMQGTLVTFP KLIIPATIAV AIAWFIWNKT ILGKNMYAVG GNAEAANVSG
     ISVFGVTMSV FAMAAVFYGF GAFFETFKAN ASAGTGQGYE LDAIASCVVG GISFNGGIGK
     LEGAVVGVII FTGLTYCLTF LGIDTNLQFV FKGLIIIAAV ALDSVKYLKR R
 
 
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