MGLC_TREPA
ID MGLC_TREPA Reviewed; 531 AA.
AC Q57321;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Galactoside transport system permease protein MglC homolog;
GN Name=mglC; OrderedLocusNames=TP_0686;
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=8921855; DOI=10.1016/0378-1119(96)00286-7;
RA Porcella S.F., Popova T.G., Hagman K.E., Penn C.W., Radolf J.D.,
RA Norgard M.V.;
RT "A mgl-like operon in Treponema pallidum, the syphilis spirochete.";
RL Gene 177:115-121(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=8988365; DOI=10.3109/10425179609020876;
RA Stamm L.V., Young N.R., Frye J.G., Hardham J.M.;
RT "Identification and sequences of the Treponema pallidum mglA and mglC
RT genes.";
RL DNA Seq. 6:293-298(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC galactoside. Probably responsible for the translocation of the
CC substrate across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
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DR EMBL; U48416; AAC44586.1; -; Genomic_DNA.
DR EMBL; U45323; AAC44750.1; -; Genomic_DNA.
DR EMBL; AE000520; AAC65649.1; -; Genomic_DNA.
DR PIR; JC5172; JC5172.
DR RefSeq; WP_010882131.1; NC_021490.2.
DR AlphaFoldDB; Q57321; -.
DR IntAct; Q57321; 2.
DR STRING; 243276.TPANIC_0686; -.
DR EnsemblBacteria; AAC65649; AAC65649; TP_0686.
DR GeneID; 57879211; -.
DR KEGG; tpa:TP_0686; -.
DR eggNOG; COG4211; Bacteria.
DR HOGENOM; CLU_481395_0_0_12; -.
DR OMA; DWFKAFL; -.
DR OrthoDB; 1254678at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR001851; ABC_transp_permease.
DR InterPro; IPR030158; MglC.
DR PANTHER; PTHR32196:SF18; PTHR32196:SF18; 1.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..531
FT /note="Galactoside transport system permease protein MglC
FT homolog"
FT /id="PRO_0000060109"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 531 AA; 57875 MW; B92EFA6BC8ABF299 CRC64;
MRDRTQCVAV PTQAFNEILD QDGQLTAYAQ RLEQLRERGS HRVALLRGEL ARIRQDQVLG
MPEKRVQVAA HRLKISEAQA VARQCKTEET QLVRKAVARV RGLFRDFDCS VRDAMREQRL
LLKQVATVQH TSASSDQREH CLAQLRQCKE ARHHAYRSLV EKSAALRNGK MTFIERVVRA
LREYSFNFDA TQFFLANGLY IAIAVFFIAC IVVAPFSGNG NLLTIPNILT ILEQSSVRMF
YAVGVAGIIL LAGTDLSIGR MVAMGSVVTG IILHPGQNIV TFFGLGPWDF TPVPMAVRVV
MSLAVSVALC VSFSLFAGFF SARLKIHPFI STLATQLIIY GVLFFGTSGT PVGSIDPYIK
DLFGGRWILG TMQGTLVTFP KLIIPATIAV AIAWFIWNKT ILGKNMYAVG GNAEAANVSG
ISVFGVTMSV FAMAAVFYGF GAFFETFKAN ASAGTGQGYE LDAIASCVVG GISFNGGIGK
LEGAVVGVII FTGLTYCLTF LGIDTNLQFV FKGLIIIAAV ALDSVKYLKR R