ID   ARLY_CERS4              Reviewed;         471 AA.
AC   Q3IZY2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=RHOS4_23340;
GN   ORFNames=RSP_0726;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000143; ABA79902.1; -; Genomic_DNA.
DR   RefSeq; WP_011338440.1; NZ_CP030271.1.
DR   RefSeq; YP_353803.1; NC_007493.2.
DR   AlphaFoldDB; Q3IZY2; -.
DR   SMR; Q3IZY2; -.
DR   STRING; 272943.RSP_0726; -.
DR   EnsemblBacteria; ABA79902; ABA79902; RSP_0726.
DR   KEGG; rsp:RSP_0726; -.
DR   PATRIC; fig|272943.9.peg.2679; -.
DR   eggNOG; COG0165; Bacteria.
DR   OMA; KKNPDVF; -.
DR   PhylomeDB; Q3IZY2; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..471
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000240760"
SQ   SEQUENCE   471 AA;  50905 MW;  913D785CD21C89A1 CRC64;
     MSDAPDPSSA ANTMWGGRFA AGPDAIMQAI NASIGFDKRL YAQDIRGSRA HAAMLAAQGI
     LTSRDAEAIG EGLLTVLSEI EAGGFPFRVE LEDIHMNVEA RLKELIGEPA GRLHTARSRN
     DQVAVDFRLW VRDQCDAAIS GIEALMRAFL AQAEAGADWV MPGFTHLQTA QPVTWGHHML
     AYVEMLARDR SRFVDARARM NECPLGAAAL AGTGFPIDRH MTAAALGFDR PTANSLDSVS
     DRDFALEFLS ASAICALHLS RFAEELVIWS SAQFRFVRLS DRWTTGSSIM PQKKNPDAAE
     LLRAKMGRVL GAAVALFTVM KGLPLTYSKD MQEDKEQVFD AADTLMLGLA AMTGMVGDMQ
     ANRESLAAAA ASGFSTATDL ADWLVRELNL PFRDAHHVTG TLVARAEARG CDLPDLSLAE
     MQEVHPGIRE DVFAVLGVEN SVRSRTSYGG TAPDNVRAQA ARWKELLGDA A