ID   MGME1_XENTR             Reviewed;         347 AA.
AC   F6SDF8; B1WAN8;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Mitochondrial genome maintenance exonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03030};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_03030};
GN   Name=mgme1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Single-stranded DNA (ssDNA) metal-dependent exonuclease
CC       involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC       exonuclease activity. Necessary for maintenance of proper 7S DNA
CC       levels. Probably involved in mitochondrial DNA (mtDNA) repair.
CC       Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in
CC       stem cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03030}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03030}.
CC   -!- SIMILARITY: Belongs to the MGME1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03030}.
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DR   EMBL; AAMC01103849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC161444; AAI61444.1; -; mRNA.
DR   RefSeq; NP_001120532.1; NM_001127060.1.
DR   AlphaFoldDB; F6SDF8; -.
DR   SMR; F6SDF8; -.
DR   PaxDb; F6SDF8; -.
DR   Ensembl; ENSXETT00000030226; ENSXETP00000030226; ENSXETG00000013803.
DR   GeneID; 100145685; -.
DR   KEGG; xtr:100145685; -.
DR   CTD; 92667; -.
DR   Xenbase; XB-GENE-1008562; mgme1.
DR   eggNOG; ENOG502QVKE; Eukaryota.
DR   HOGENOM; CLU_068902_0_0_1; -.
DR   InParanoid; F6SDF8; -.
DR   OrthoDB; 1513785at2759; -.
DR   TreeFam; TF320375; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013803; Expressed in egg cell and 11 other tissues.
DR   ExpressionAtlas; F6SDF8; baseline.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
DR   Gene3D; 3.90.320.10; -; 1.
DR   HAMAP; MF_03030; MGME1; 1.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Exonuclease; Hydrolase; Mitochondrion; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..347
FT                   /note="Mitochondrial genome maintenance exonuclease 1"
FT                   /id="PRO_0000421765"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        259
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   347 AA;  39949 MW;  965750449C8A2466 CRC64;
     MKPLQQIHLT CRRIIRDVLQ HKSFLPAFIS TSCTCLSRKK KHNGYDEVNQ AKYEGLVRTV
     TASRISPQTP DRLFEEDNFL FGKVVKSKTA TQTPEPKAPQ NWVPLSNPNK VSLPLEKTDF
     DLPLKISLPA RNHMANGTIP SVTRILQQTM PMEQAFYLER WKQRMIMELG EQGFAEYTAA
     LFSQGKQFHM QLEDLLLALD HGKKEEPEGS TGYLSSVQHV LTDIIGVKSL ESAVHHSELQ
     YLGLVDCVAE YRQKLCVIDW KTSEKPKPYI RDTFDNPLQI AAYIGAINHD NNYNFQVNCG
     LIVVAYKDGS PAHTHFMDTD LCLHFWNKWL LRLEEYKKKK EEKEKQQ