MGN2_BOVIN
ID MGN2_BOVIN Reviewed; 148 AA.
AC Q0VC92;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Protein mago nashi homolog 2;
GN Name=MAGOHB; Synonyms=MAGOH2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal spinal cord;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for pre-mRNA splicing as component of the
CC spliceosome. Plays a redundant role with MAGOH in the exon junction
CC complex and in the nonsense-mediated decay (NMD) pathway.
CC {ECO:0000250|UniProtKB:Q96A72}.
CC -!- SUBUNIT: Component of the pre-catalytic, catalytic and post-catalytic
CC spliceosome complexes. Heterodimer with RBM8A. Core component of the
CC mRNA splicing-dependent exon junction complex (EJC); the core complex
CC contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A.
CC {ECO:0000250|UniProtKB:Q96A72}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96A72}.
CC -!- SIMILARITY: Belongs to the mago nashi family. {ECO:0000305}.
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DR EMBL; BC120291; AAI20292.1; -; mRNA.
DR RefSeq; NP_001069720.1; NM_001076252.1.
DR AlphaFoldDB; Q0VC92; -.
DR SMR; Q0VC92; -.
DR IntAct; Q0VC92; 2.
DR STRING; 9913.ENSBTAP00000025615; -.
DR PaxDb; Q0VC92; -.
DR PRIDE; Q0VC92; -.
DR Ensembl; ENSBTAT00000025615; ENSBTAP00000025615; ENSBTAG00000019235.
DR GeneID; 541013; -.
DR KEGG; bta:541013; -.
DR CTD; 55110; -.
DR VEuPathDB; HostDB:ENSBTAG00000019235; -.
DR eggNOG; KOG3392; Eukaryota.
DR GeneTree; ENSGT00390000003156; -.
DR HOGENOM; CLU_109497_1_1_1; -.
DR InParanoid; Q0VC92; -.
DR OMA; IRKEMWI; -.
DR OrthoDB; 1373136at2759; -.
DR TreeFam; TF300128; -.
DR Reactome; R-BTA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000019235; Expressed in oocyte and 106 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0035145; C:exon-exon junction complex; IBA:GO_Central.
DR GO; GO:1990501; C:exon-exon junction subcomplex mago-y14; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:Ensembl.
DR GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR CDD; cd11295; Mago_nashi; 1.
DR Gene3D; 3.30.1560.10; -; 1.
DR InterPro; IPR004023; Mago_nashi.
DR InterPro; IPR036605; Mago_nashi_sf.
DR PANTHER; PTHR12638; PTHR12638; 1.
DR Pfam; PF02792; Mago_nashi; 1.
DR SUPFAM; SSF89817; SSF89817; 1.
PE 2: Evidence at transcript level;
KW Acetylation; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96A72"
FT CHAIN 2..148
FT /note="Protein mago nashi homolog 2"
FT /id="PRO_0000323380"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96A72"
SQ SEQUENCE 148 AA; 17308 MW; 0DDD3FD3ADD09E28 CRC64;
MAMASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK EAYVHKSVME
ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS FTTSKIGSLI DVNQSKDPEG
LRVFYYLVQD LKCLVFSLIG LHFKIKPI