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MGN_CHICK
ID   MGN_CHICK               Reviewed;         146 AA.
AC   P50594; Q8AW85;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protein mago nashi homolog;
GN   Name=MAGOH;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ivarie R.D., Andacht T.M.;
RT   "Avian mago nashi gene.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RC   TISSUE=Heart;
RX   PubMed=8875073;
RX   DOI=10.1002/(sici)1097-0177(199609)207:1<25::aid-aja3>3.0.co;2-y;
RA   Shi N., Antin P.B., Akimoto K., Morkin E.;
RT   "Expression of avian glypican is developmentally regulated.";
RL   Dev. Dyn. 207:25-34(1996).
CC   -!- FUNCTION: Core component of the splicing-dependent multiprotein exon
CC       junction complex (EJC) deposited at splice junctions on mRNAs. The EJC
CC       is a dynamic structure consisting of core proteins and several
CC       peripheral nuclear and cytoplasmic associated factors that join the
CC       complex only transiently either during EJC assembly or during
CC       subsequent mRNA metabolism. The EJC marks the position of the exon-exon
CC       junction in the mature mRNA for the gene expression machinery and the
CC       core components remain bound to spliced mRNAs throughout all stages of
CC       mRNA metabolism thereby influencing downstream processes including
CC       nuclear mRNA export, subcellular mRNA localization, translation
CC       efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBUNIT: Part of the EJC core complex that contains CASC3, EIF4A3,
CC       MAGOH and RBM8A. {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61326}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:P61326}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P61326}. Note=Travels to the cytoplasm as part
CC       of the exon junction complex (EJC) bound to mRNA.
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SIMILARITY: Belongs to the mago nashi family. {ECO:0000305}.
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DR   EMBL; AF383945; AAN76523.1; -; mRNA.
DR   EMBL; L29089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_989656.1; NM_204325.2.
DR   AlphaFoldDB; P50594; -.
DR   SMR; P50594; -.
DR   STRING; 9031.ENSGALP00000017367; -.
DR   PaxDb; P50594; -.
DR   PRIDE; P50594; -.
DR   VEuPathDB; HostDB:geneid_374226; -.
DR   eggNOG; KOG3392; Eukaryota.
DR   HOGENOM; CLU_109497_1_1_1; -.
DR   InParanoid; P50594; -.
DR   PhylomeDB; P50594; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035145; C:exon-exon junction complex; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   CDD; cd11295; Mago_nashi; 1.
DR   Gene3D; 3.30.1560.10; -; 1.
DR   InterPro; IPR004023; Mago_nashi.
DR   InterPro; IPR036605; Mago_nashi_sf.
DR   PANTHER; PTHR12638; PTHR12638; 1.
DR   Pfam; PF02792; Mago_nashi; 1.
DR   SUPFAM; SSF89817; SSF89817; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..146
FT                   /note="Protein mago nashi homolog"
FT                   /id="PRO_0000174149"
SQ   SEQUENCE   146 AA;  17106 MW;  4880886A9E045F18 CRC64;
     MASDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL
     KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR
     VFYYLVQDLK CLVFSLIGLH FKIKPI
 
 
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