ID   MGN_SALSA               Reviewed;         147 AA.
AC   B9ENE7;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Protein mago nashi homolog;
GN   Name=magoh;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Core component of the splicing-dependent multiprotein exon
CC       junction complex (EJC) deposited at splice junctions on mRNAs. The EJC
CC       is a dynamic structure consisting of core proteins and several
CC       peripheral nuclear and cytoplasmic associated factors that join the
CC       complex only transiently either during EJC assembly or during
CC       subsequent mRNA metabolism. The EJC marks the position of the exon-exon
CC       junction in the mature mRNA for the gene expression machinery and the
CC       core components remain bound to spliced mRNAs throughout all stages of
CC       mRNA metabolism thereby influencing downstream processes including
CC       nuclear mRNA export, subcellular mRNA localization, translation
CC       efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBUNIT: Part of the EJC core complex that contains casc3, eif4a3,
CC       magoh and rbm8a. {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61326}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:P61326}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P61326}. Note=Travels to the cytoplasm as part
CC       of the exon junction complex (EJC) bound to mRNA.
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SIMILARITY: Belongs to the mago nashi family. {ECO:0000305}.
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DR   EMBL; BT057172; ACM09044.1; -; mRNA.
DR   RefSeq; XP_014024353.1; XM_014168878.1.
DR   AlphaFoldDB; B9ENE7; -.
DR   SMR; B9ENE7; -.
DR   STRING; 8030.ENSSSAP00000019831; -.
DR   GeneID; 106584057; -.
DR   KEGG; sasa:106584057; -.
DR   OMA; IRKEMWI; -.
DR   OrthoDB; 1373136at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa23.
DR   Bgee; ENSSSAG00000009680; Expressed in testis and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035145; C:exon-exon junction complex; IEA:InterPro.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd11295; Mago_nashi; 1.
DR   Gene3D; 3.30.1560.10; -; 1.
DR   InterPro; IPR004023; Mago_nashi.
DR   InterPro; IPR036605; Mago_nashi_sf.
DR   PANTHER; PTHR12638; PTHR12638; 1.
DR   Pfam; PF02792; Mago_nashi; 1.
DR   SUPFAM; SSF89817; SSF89817; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; mRNA transport;
KW   Nonsense-mediated mRNA decay; Nucleus; Reference proteome; RNA-binding;
KW   Translation regulation; Transport.
FT   CHAIN           1..147
FT                   /note="Protein mago nashi homolog"
FT                   /id="PRO_0000378585"
SQ   SEQUENCE   147 AA;  17223 MW;  0AF29A474A15740E CRC64;
     MSTSDFYLRY YVGHKGKFGH EFLEFEFRPD GKLRYANNSN YKNDVMIRKE AYVHKSVMEE
     LKRIIDDSEI TKEDDALWPP PDRVGRQELE IVIGDEHISF TTSKIGSLID VNQSKDPEGL
     RVFYYLVQDL KCLVFSLIGL HFKIKPI