ID   MGN_XENLA               Reviewed;         146 AA.
AC   O42149; Q6B0K3;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein mago nashi homolog;
DE   AltName: Full=Xl-mago;
GN   Name=magoh;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9272960; DOI=10.1242/dev.124.16.3197;
RA   Newmark P.A., Mohr S.E., Gong L., Boswell R.E.;
RT   "Mago nashi mediates the posterior follicle cell-to-oocyte signal to
RT   organize axis formation in Drosophila.";
RL   Development 124:3197-3207(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of the splicing-dependent multiprotein exon
CC       junction complex (EJC) deposited at splice junctions on mRNAs. The EJC
CC       is a dynamic structure consisting of core proteins and several
CC       peripheral nuclear and cytoplasmic associated factors that join the
CC       complex only transiently either during EJC assembly or during
CC       subsequent mRNA metabolism. The EJC marks the position of the exon-exon
CC       junction in the mature mRNA for the gene expression machinery and the
CC       core components remain bound to spliced mRNAs throughout all stages of
CC       mRNA metabolism thereby influencing downstream processes including
CC       nuclear mRNA export, subcellular mRNA localization, translation
CC       efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBUNIT: Part of the EJC core complex that contains casc3, eif4a3,
CC       magoh and rbm8a. {ECO:0000250|UniProtKB:P61326}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61326}. Nucleus
CC       speckle {ECO:0000250|UniProtKB:P61326}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P61326}. Note=Travels to the cytoplasm as part
CC       of the exon junction complex (EJC) bound to mRNA.
CC       {ECO:0000250|UniProtKB:P61326}.
CC   -!- SIMILARITY: Belongs to the mago nashi family. {ECO:0000305}.
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DR   EMBL; AF007860; AAB66720.1; -; mRNA.
DR   EMBL; BC053764; AAH53764.1; -; mRNA.
DR   RefSeq; NP_001079724.1; NM_001086255.1.
DR   AlphaFoldDB; O42149; -.
DR   SMR; O42149; -.
DR   MaxQB; O42149; -.
DR   DNASU; 379411; -.
DR   GeneID; 379411; -.
DR   KEGG; xla:379411; -.
DR   CTD; 379411; -.
DR   Xenbase; XB-GENE-493544; magoh.L.
DR   OMA; VSECEIM; -.
DR   OrthoDB; 1373136at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 379411; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035145; C:exon-exon junction complex; IEA:InterPro.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd11295; Mago_nashi; 1.
DR   Gene3D; 3.30.1560.10; -; 1.
DR   InterPro; IPR004023; Mago_nashi.
DR   InterPro; IPR036605; Mago_nashi_sf.
DR   PANTHER; PTHR12638; PTHR12638; 1.
DR   Pfam; PF02792; Mago_nashi; 1.
DR   SUPFAM; SSF89817; SSF89817; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..146
FT                   /note="Protein mago nashi homolog"
FT                   /id="PRO_0000174150"
SQ   SEQUENCE   146 AA;  17078 MW;  6A417661BE1CE060 CRC64;
     MGSDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL
     KRIIDDSEVT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR
     VFYYLVQDLK CLVFSLIGLH FKIKPI