MGP3_MYCGE
ID MGP3_MYCGE Reviewed; 1053 AA.
AC P22747; Q49257; Q49284; Q49385; Q49481; Q49482;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Mgp-operon protein 3;
DE Short=Mgp3;
DE AltName: Full=ORF-3 protein;
DE Flags: Precursor;
GN OrderedLocusNames=MG192;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=2583522; DOI=10.1016/0378-1119(89)90051-6;
RA Inamine J.M., Loechel S., Collier A.M., Barile M.F., Hu P.-C.;
RT "Nucleotide sequence of the MgPa (mgp) operon of Mycoplasma genitalium and
RT comparison to the P1 (mpp) operon of Mycoplasma pneumoniae.";
RL Gene 82:259-267(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-133; 260-370; 442-513; 770-903 AND
RP 965-1053.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 770-965.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map of
RT Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
RN [5]
RP SEQUENCE REVISION TO 419, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT "Essential genes of a minimal bacterium.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Probably essential, it was not disrupted in a
CC global transposon mutagenesis study. {ECO:0000269|PubMed:16407165}.
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DR EMBL; M31431; AAA25421.1; -; Genomic_DNA.
DR EMBL; L43967; AAC71411.2; -; Genomic_DNA.
DR EMBL; U02124; AAD12399.1; -; Genomic_DNA.
DR EMBL; U02161; AAD12443.1; -; Genomic_DNA.
DR EMBL; U34967; AAA88890.1; -; Genomic_DNA.
DR EMBL; U02157; AAD12439.1; -; Genomic_DNA.
DR EMBL; U34970; AAA88899.1; -; Genomic_DNA.
DR EMBL; X61525; CAB98130.1; -; Genomic_DNA.
DR EMBL; X61527; CAB98131.1; -; Genomic_DNA.
DR PIR; C64221; C64221.
DR AlphaFoldDB; P22747; -.
DR SMR; P22747; -.
DR STRING; 243273.MG_192; -.
DR EnsemblBacteria; AAC71411; AAC71411; MG_192.
DR KEGG; mge:MG_192; -.
DR eggNOG; ENOG5030S6X; Bacteria.
DR HOGENOM; CLU_268940_0_0_14; -.
DR OMA; KLNESWP; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR InterPro; IPR045839; MGP3_C.
DR InterPro; IPR007885; MgpC.
DR Pfam; PF19342; MGP3_C; 1.
DR Pfam; PF05220; MgpC; 1.
PE 3: Inferred from homology;
KW Cell adhesion; Cell membrane; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..1053
FT /note="Mgp-operon protein 3"
FT /id="PRO_0000021720"
FT TRANSMEM 946..966
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 162..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 60..68
FT /note="LDSSYQIAD -> MIKPLPLLS (in Ref. 3; AAD12399)"
FT /evidence="ECO:0000305"
FT CONFLICT 125..126
FT /note="TM -> SV (in Ref. 3; AAD12399)"
FT /evidence="ECO:0000305"
FT CONFLICT 475..482
FT /note="TNNGTTGP -> SNQISSGT (in Ref. 3; AAD12439)"
FT /evidence="ECO:0000305"
FT CONFLICT 477
FT /note="N -> S (in Ref. 3; AAA88890)"
FT /evidence="ECO:0000305"
FT CONFLICT 898..903
FT /note="SVSPRI -> MSHQVS (in Ref. 3; CAB98131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1053 AA; 114448 MW; C991B158B389CAA5 CRC64;
MKTMRKQIYK KAYWLLLPFL PLALANTFLV KEDSKNVTAY TPFATPITDS KSDLVSLAQL
DSSYQIADQT IHNTNLFVLF KSRDVKVKYE SSGSNNISFD STSQGEKPSY VVEFTNSTNI
GIKWTMVKKY QLDVPNVSSD MNQVLKNLIL EQPLTKYTLN SSLAKEKGKT QREVHLGSGQ
ANQWTSQRNQ HDLNNNPSPN ASTGFKLTTG NAYRKLSESW PIYEPIDGTK QGKGKDSSGW
SSTEENEAKN DAPSVSGGGS SSGTFNKYLN TKQALESIGI LFDDQTPRNV ITQLYYASTS
KLAVTNNHIV VMGNSFLPSM WYWVVERSAQ ENASNKPTWF ANTNLDWGED KQKQFVENQL
GYKETTSTNS HNFHSKSFTQ PAYLISGIDS VNDQIIFSGF KAGSVGYDSS SSSSSSSSSS
TKDQALAWST TTSLDSKTGY KDLVTNDTGL NGPINGSFSI QDTFSFVVPY SGNHTNNGTT
GPIKTAYPVK KDQKSTVKIN SLINATPLNS YGDEGIGVFD ALGLNYNFKS NQERLPSRTD
QIFVYGIVSP NELRSAKSSA DSTGSDTKVN WSNTQSRYLP VPYNYSEGII DADGFKRPEN
RGASVTTFSG LKSIAPDGFA NSIANFSVGL KAGIDPNPVM SGKKANYGAV VLTRGGVVRL
NFNPGNDSLL STTDNNIAPI SFSFTPFTAA ESAVDLTTFK EVTYNQESGL WSYIFDSSLK
PSHDGKQTPV TDNMGFSVIT VSRTGIELNQ DQATTTLDVA PSALAVQSGI QSTTQTLTGV
LPLSEEFSAV IAKDSDQNKI DIYKNNNGLF EIDTQLSNSV ATNNGGLAPS YTENRVDAWG
KVEFADNSVL QARNLVDKTV DEIINTPEIL NSFFRFTPAF EDQKATLVAT KQSDTSLSVS
PRIQFLDGNF YDLNSTIAGV PLNIGFPSRV FAGFAALPAW VIPVSVGSSV GILFILLVLG
LGIGIPMYRV RKLQDASFVN VFKKVDTLTT AVGSVYKKII TQTGVVKKAP SALKAANPSV
KKPAAFLKPP VQPPSKPEGE QKAVEVKSEE TKS
