ID   MGP_CHICK               Reviewed;         103 AA.
AC   O42413;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Precursor;
GN   Name=MGP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cartilage;
RX   PubMed=9434150; DOI=10.1016/s0167-4781(97)00155-3;
RA   Wiedemann M., Trueb B., Belluoccio D.;
RT   "Molecular cloning of avian matrix Gla protein.";
RL   Biochim. Biophys. Acta 1395:47-49(1998).
CC   -!- FUNCTION: Associates with the organic matrix of bone and cartilage.
CC       Thought to act as an inhibitor of bone formation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: In 16-day-old embryo, expressed at high level in
CC       the sternum and tibia, at low level in skeletal muscle, heart and
CC       gizzard. Not present in skin, liver and brain.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its function.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
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DR   EMBL; Y13903; CAA74201.1; -; mRNA.
DR   RefSeq; NP_990375.1; NM_205044.1.
DR   AlphaFoldDB; O42413; -.
DR   SMR; O42413; -.
DR   STRING; 9031.ENSGALP00000019149; -.
DR   PaxDb; O42413; -.
DR   Ensembl; ENSGALT00000019173; ENSGALP00000019149; ENSGALG00000011740.
DR   GeneID; 395912; -.
DR   KEGG; gga:395912; -.
DR   CTD; 4256; -.
DR   VEuPathDB; HostDB:geneid_395912; -.
DR   eggNOG; ENOG502S45A; Eukaryota.
DR   GeneTree; ENSGT00390000003753; -.
DR   HOGENOM; CLU_177119_1_0_1; -.
DR   InParanoid; O42413; -.
DR   OMA; MESYEIN; -.
DR   OrthoDB; 1512503at2759; -.
DR   PhylomeDB; O42413; -.
DR   TreeFam; TF330920; -.
DR   PRO; PR:O42413; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000011740; Expressed in lung and 9 other tissues.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR027118; MGP.
DR   PANTHER; PTHR10109; PTHR10109; 1.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   2: Evidence at transcript level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Osteogenesis; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..103
FT                   /note="Matrix Gla protein"
FT                   /id="PRO_0000011117"
FT   DOMAIN          52..98
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         21
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         57
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         61
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         68
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         72
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   DISULFID        74..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ   SEQUENCE   103 AA;  12266 MW;  2BD458980F85047C CRC64;
     MRALIVLVLL AVLVMAATCY ESHESMESHE YLNPFLNRQR ANGFIRDDTG LRAVLQERIR
     ERNKAPQERQ REICEDFHLC EQYALNHGYP AAYRHYFGRR RNK