ID   MGP_PIG                 Reviewed;         103 AA.
AC   Q8MJ39;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Precursor;
GN   Name=MGP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Laize V., Cancela M.L.;
RT   "Identification of Sus scrofa (pig) matrix Gla protein (MGP) by comparative
RT   genomics.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with the organic matrix of bone and cartilage.
CC       Thought to act as an inhibitor of bone formation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its function.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF525316; AAM83094.1; -; mRNA.
DR   RefSeq; NP_999281.1; NM_214116.1.
DR   AlphaFoldDB; Q8MJ39; -.
DR   SMR; Q8MJ39; -.
DR   STRING; 9823.ENSSSCP00000000637; -.
DR   PaxDb; Q8MJ39; -.
DR   PeptideAtlas; Q8MJ39; -.
DR   PRIDE; Q8MJ39; -.
DR   Ensembl; ENSSSCT00000042794; ENSSSCP00000059606; ENSSSCG00000037697.
DR   Ensembl; ENSSSCT00005024542; ENSSSCP00005014791; ENSSSCG00005015624.
DR   Ensembl; ENSSSCT00015025218; ENSSSCP00015009827; ENSSSCG00015018989.
DR   Ensembl; ENSSSCT00025065569; ENSSSCP00025027969; ENSSSCG00025048192.
DR   Ensembl; ENSSSCT00030074614; ENSSSCP00030034135; ENSSSCG00030053503.
DR   Ensembl; ENSSSCT00040080771; ENSSSCP00040034999; ENSSSCG00040059431.
DR   Ensembl; ENSSSCT00045036706; ENSSSCP00045025545; ENSSSCG00045021392.
DR   Ensembl; ENSSSCT00050054353; ENSSSCP00050022924; ENSSSCG00050040192.
DR   Ensembl; ENSSSCT00055028557; ENSSSCP00055022754; ENSSSCG00055014465.
DR   Ensembl; ENSSSCT00060002122; ENSSSCP00060000679; ENSSSCG00060001719.
DR   GeneID; 397206; -.
DR   KEGG; ssc:397206; -.
DR   CTD; 4256; -.
DR   VGNC; VGNC:90201; MGP.
DR   eggNOG; ENOG502S45A; Eukaryota.
DR   GeneTree; ENSGT00390000003753; -.
DR   HOGENOM; CLU_177119_1_0_1; -.
DR   InParanoid; Q8MJ39; -.
DR   OMA; MESYEIN; -.
DR   OrthoDB; 1512503at2759; -.
DR   TreeFam; TF330920; -.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000037697; Expressed in subcutaneous adipose tissue and 41 other tissues.
DR   ExpressionAtlas; Q8MJ39; baseline and differential.
DR   Genevisible; Q8MJ39; SS.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR027118; MGP.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PANTHER; PTHR10109; PTHR10109; 1.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Osteogenesis; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..103
FT                   /note="Matrix Gla protein"
FT                   /id="PRO_0000011112"
FT   DOMAIN          51..97
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         21
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         56
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         60
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         67
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         71
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   DISULFID        73..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ   SEQUENCE   103 AA;  12142 MW;  C140BAB8C4249BC9 CRC64;
     MKSLLLLSVL AALAVAALCY ESHESLESYE INPFLNRRNA NTFISPQQRW RAKAQERIRE
     LNKPPYELNR EACDDYKLCE RYAMVYGYNA AYNRYFRQRP GAK