ID   MGP_PONAB               Reviewed;         103 AA.
AC   Q5RDP6;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Precursor;
GN   Name=MGP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with the organic matrix of bone and cartilage.
CC       Thought to act as an inhibitor of bone formation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its function.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
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DR   EMBL; CR857858; CAH90111.1; -; mRNA.
DR   RefSeq; NP_001125014.1; NM_001131542.1.
DR   AlphaFoldDB; Q5RDP6; -.
DR   SMR; Q5RDP6; -.
DR   GeneID; 100171893; -.
DR   KEGG; pon:100171893; -.
DR   CTD; 4256; -.
DR   InParanoid; Q5RDP6; -.
DR   OrthoDB; 1512503at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR027118; MGP.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PANTHER; PTHR10109; PTHR10109; 1.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   3: Inferred from homology;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Osteogenesis; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..96
FT                   /note="Matrix Gla protein"
FT                   /id="PRO_0000011113"
FT   PROPEP          97..103
FT                   /note="Removed in mature form; probably by carboxypeptidase
FT                   N"
FT                   /id="PRO_0000011114"
FT   DOMAIN          51..97
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         21
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07507"
FT   MOD_RES         56
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         60
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         67
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   MOD_RES         71
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000250|UniProtKB:P07507,
FT                   ECO:0000255|PROSITE-ProRule:PRU00463"
FT   DISULFID        73..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ   SEQUENCE   103 AA;  12322 MW;  D457FB7C967843CA CRC64;
     MKSLVLLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NIFISPQQRW RAKVQERIRE
     RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRERR GAK